介入技术治疗下肢手术后深静脉血栓形成的效果与分析

Interventional Therapy for Deep Venous Thrombosis after Lower Extremity Surgery

目的:探究介入技术在治疗下肢手术后深静脉血栓形成的效果与分析。方法:选择2010年1月至2018年12月期间在我院接受治疗的136例患下肢深静脉血栓的患者,根据数字表法随机分为观察组和对照组,每组68例;对照组采用常规抗凝治疗,观察组在抗凝的基础上联合导管溶栓介入治疗;对两组患治疗后的临床疗效、治疗前后肢体周径差、径一健肢周径、腘静脉血流速度及血管内径以及两组血浆PAl-1水平和临床生化指标进行比较与分析。结果:两组患者治疗后,观察组有效率为86.76%,显著高于对照组67.65%(P<0.05);治疗前,两组患者大腿和小腿的周经差、腘静脉血管内径和血流速度均无显著差异(P>0.05),治疗后,两组患者的腿周经均显著降低,组间比较,观察组显著的小于对照组,具有统计学意义(P<0.05);观察组和对照组的血管内径和血液流速具有显著的差异,具有统计学意义(P<0.05)。治疗后,观察组的PAI-1指标显著高于对照组,而t-PA显著的低于对照组,均具有统计学意义(P<0.05)。观察组的Lp(a)、D-D、FIB、AT、PS和PC水水平均低于对照组,差异显著,具有统计学意义(P<0.05),验组的PLT指标显著的高于对照组(P<0.05),虽然观察组的MPV指标高于对照组,但无统计学意义(P>0.05)。结论:导管溶栓介入技术在治疗下肢手术后深静脉血栓形中能有效清除管腔内血栓,效果优于单纯抗凝治疗,值得在临床推广。

Objective: To explore the effect and analysis of interventional technique in the treatment of deep venous thrombosis after lower extremity surgery. Methods: 136 patients with deep venous thrombosis of lower extremities who were treated in our hospital from January 2010 to December 2018 were divided into observation group and control group according to the digital table method, 68 cases in each group. The control group was treated with conventional anticoagulation therapy, while the observation group was treated with catheter thrombolytic interventional therapy on the basis of the control group. The perimeter of one healthy limb, popliteal vein blood flow velocity and intravascular diameter, plasma PAl-1 level and clinical biochemical indexes were compared and analyzed between the two groups. Results: After treatment, the effective rate of the observation group was 86.76%, significantly higher than that of the control group (67.65%(P > 0.05). Before treatment, there were no significant differences in the menstrual difference between the thighs and legs, popliteal vein internal diameter and blood flow velocity between the two groups (P > 0.05). After treatment, the menstrual changes of the legs of the two groups were significantly reduced. The comparison between the two groups showed that the experimental group was significantly smaller than that of the control group, with statistical significance. Significance (P < 0.05);experimental group and control group had significant differences in vascular diameter and blood flow velocity (P < 0.05). After treatment, PAI-1 in the experimental group was significantly higher than that in the control group, while t-PA was significantly lower than that in the control group, with statistical significance (P < 0.05). The levels of Lp (a), D-D, FIB, AT, PS and P C in the experimental group were lower than those in the control group, with significant difference (P < 0.05). The PLT index in the experimental group was significantly higher than that in the control group (P < 0.05). Although the MPV index in the experimental group was higher than that in the control group, there was no statistical significance (P > 0.05). Conclusion: Catheter thrombolysis interventional technique can effectively remove intraluminal thrombosis in the treatment of deep venous thrombosis after lower limb surgery, and its effect is better than anticoagulation therapy alone, which is worthy of clinical promotion.