老年健忘(脑动脉硬化)中医证型分布规律研究

Distribution Regularity of TCM Syndromes in Senescent Forgetfulness due to Cerebral Arteriosclerosis

目的:探讨老年健忘(脑动脉硬化)中医证型分布规律。方法:通过回顾性分析,对100例老年健忘(脑动脉硬化)患者进行调查研究,对其中医证型的分布规律进行分析,对其中医证型、C反应蛋白(CRP)、空腹血糖(FPG)、血脂以及同型半胱氨酸(Hcy)与老年健忘(脑动脉硬化)之间的关系进行探讨研究。结果:100例老年健忘(脑动脉硬化)患者中风痰阻络型所占比例为51.00%,肝阳暴亢型所占比例为35.00%,气虚血瘀型所占比例为6.00%,阴虚风动型所占比例为8.00%,不同中医证型老年健忘(脑动脉硬化)指数进行比较,结果发现,阴虚风动型动态动脉硬化指数以及相应对称性动态动脉硬化指数明显高于气虚血瘀型以及肝阳暴亢型,差异具有统计学意义(P<0.05),老年健忘(脑动脉硬化)患者CRP、FPG、血脂以及Hcy在各个证型中均出现不同程度的改变,但风痰阻络型CRP、血脂以及Hcy都出现明显变化,差异具有统计学意义(P<0.05),FPG在证型中没有明显变化,差异不具有统计学意义(P>0.05),但气虚血瘀型中FPG变化比较明显,差异具有统计学意义(P<0.05)。结论:老年健忘(脑动脉硬化)中医辨证主要为风痰阻络和肝阳暴亢,对患者的CRP、FPG、血脂以及Hcy等指标进行测定,能为中医辨证分型提供一定的理论依据。

Objective: To explore the distribution regularity of TCM syndromes in senescent forgetfulness due to cerebral arteriosclerosis. Methods: Through retrospective analysis, 100 cases of senescent forgetfulness due to cerebral arteriosclerosis were investigated trying to find the distribution regularity of its TCM syndromes. The relationship of TCM syndromes with C reactive protein(CRP), fasting plasma glucose(FPG), blood lipid, and homocysteine(Hcy) was studied in senescent forgetfulness due to cerebral arteriosclerosis. Results: In the 100 cases, the syndrome of wind-phlegm blocking the collaterals accounted for 51%, the syndrome of hyperactivity of Liver-yang accounted for 35%, the syndrome of qi deficiency and blood stasis accounted for 6%, and the syndrome of yin deficiency with wind stirring accounted for 8%. Indexes of cerebral arteriosclerosis were compared among different syndromes;the results showed that they were significantly higher in the syndrome of yin deficiency with wind stirring than those in the syndrome of qi deficiency and blood stasis and those in the syndrome of hyperactivity of Liver-yang( P <0.05). The changes of CRP, FPG, blood lipid, and Hcy were seen in different syndromes, but the changes in the syndrome of wind-phlegm blocking the collaterals were most significant( P <0.05). The change of FPG was significant in the syndrome of qi deficiency and blood stasis( P <0.05);however, there was no difference in FPG change among the other syndromes( P >0.05). Conclusion: The main syndomes of senescent forgetfulness due to cerebral arteriosclerosis are wind-phlegm blocking the collaterals and hyperactivity of Liver-yang. CRP, FPG, blood lipids, and Hcy can provide reference for TCM syndrome differentiation.