恶性脑胶质瘤中FOXC2的表达情况及其对预后的影响

Expression of FOXC2 in malignant glioma and its effect on prognosis

目的了解恶性脑胶质瘤中FOXC2的表达情况及其对预后影响。方法收集郑州大学第一附属医院2015年10月至2017年10月经治恶性脑胶质瘤100例(胶质瘤组)及因外伤等非肿瘤原因切除脑组织者100例(对照组),对切除标本行免疫组化了解FOXC2的表达情况及其对预后影响。结果胶质瘤组FOXC2表达阳性率高于对照组,差异有统计学意义(P<0.05)。在恶性脑胶质瘤中,FOXC2表达在年龄(≥50岁组与<50岁组)、性别间差异无统计学意义(均P>0.05)。恶性脑胶质瘤WHO分级各分级之间FOXC2表达情况差异有统计学意义(P<0.05)。FOXC2表达情况是恶性脑胶质瘤生存期预测的独立危险因素(RR=5.2,P<0.05)。FOXC2表达阳性组存活时间短于阴性表达组,差异有统计学意义(χ^2=20.895,P<0.05)。结论 FOXC2表达水平与恶性脑胶质瘤临床分级、预后等密切相关。

Objective To investigate the expression of FOXC2 in malignant gliomas and its impact on prognosis.Methods One hundred cases of malignant glioma treated in the First Affiliated Hospital of Zhengzhou University from October 2015 to October 2017(glioma group) and 100 cases of non-tumor resection of brain tissue due to trauma were collected(control group). Immunohistochemistry was used to detect the expression of FOXC2 and its effect on prognosis was observed.Results The positive rate of FOXC2 expression in glioma group was higher than that in control group, and the difference was statistically significant(P<0.05). In malignant gliomas patients, FOXC2 expression were not significantly different in age(≥50-year-old group and <50-year-old group) and gender(all P>0.05). There was a difference in the expression of FOXC2 between the grades of WHO grading of malignant glioma, and the difference was statistically significant(P<0.05). FOXC2 expression was an independent risk factor for malignant glioma survival(RR=5.2, P<0.05). The survival time of the FOXC2 positive group was lower than that of the negative expression group(χ^2=20.895, P<0.05).Conclusion The expression level of FOXC2 is closely related to the clinical grade and prognosis of malignant glioma.