高血压患者抑郁情绪的筛查及其与炎症因子和血管紧张素Ⅱ的相关性研究

Relevant Research of Screening of Depression and Its Inflammatory Factors and Angiotensin Ⅱ in Patients with Hypertension

目的:调查高血压患者中抑郁发生情况并分析高血压患者抑郁情绪与炎症因子和血管紧张素Ⅱ的相关性。方法:选取2017年1月~7月期间在某院门诊就诊的原发性高血压患者210例作为高血压组,另同期选取门诊就诊的健康志愿者210例作为对照组,采用一般资料调查问卷和Zung编制的抑郁自评量表(SDS)评估高血压患者抑郁情况,并检测两组患者血清C反应蛋白(CRP)、人可溶性细胞间粘附分子1(sICAM-1)及血管紧张素Ⅱ水平。结果:(1)调查发现,210例高血压患者中发生抑郁症状77例,发生率为36.67%;其中轻度抑郁发生率为23.80%,中度抑郁发生率10.47%,重度抑郁发生率2.38%;(2)高血压伴抑郁组SDS评分、CRP、sICAM-1及血管紧张素Ⅱ水平>高血压不伴抑郁组>对照组,组间比较差异有统计学意义(P<0.05);(3)经双变量Pearson相关性分析检验证实,抑郁情绪与炎症因子和血管紧张素Ⅱ均呈正相关(r>0,P<0.05)。结论:高血压患者抑郁发生率较高,且抑郁情绪与炎症因子、血管紧张素Ⅱ呈正相关。

Objective: To investigate the incidence of depression in patients with hypertension and to analyze the correlation between depression and inflammatory factors and angiotensin Ⅱ. Methods: 210 patients with essential hypertension in a hospital from January to July 2017 were selected as the hypertension group, and 210 healthy volunteers in the same period were selected as the control group. The depression status of hypertension patients was assessed by general information questionnaire and self-rating depression scale(SDS) compiled by Zung, and the serum C-reactive protein(CRP) and sexual intercellular adhesion molecule-1(sICAM-1) and angiotensin Ⅱ levels of the two groups were detected. Results:(1) The survey found that 77 of 210 hypertensive patients had depressive symptoms, the incidence of which was 36.67%. The incidence of mild depression was 23.80%, moderate depression was 10.47%, and severe depression was 2.38%.(2) SDS score, CRP, sICAM-1 and angiotensin Ⅱ level in hypertension with depression grouP> hypertension without depression grouP>control group, there was significant difference between the two groups(P<0.05).(3) Bivariate Pearson correlation analysis confirmed that depression was positively correlated with inflammatory factors and angiotensin Ⅱ(r>0, P<0.05). Conclusion: The incidence of depression is high in patients with hypertension, and depression is positively correlated with inflammatory factors and angiotensin Ⅱ.