IL-33及其受体sST2在SLE患儿血清中的表达及意义

Expressions and roles of serum IL-33 and sST2 in children with systemic lupus erythematosus

目的探讨系统性红斑狼疮(SLE)患儿血清白细胞介素(IL)33及其受体可溶性致癌抑制因子2(sST2)的表达及意义。方法采用酶联免疫吸附试验(ELISA)检测32例SLE患儿(SLE组)和50名体检健康儿童(正常对照组)的血清IL-33、sST2水平,并分析二者与疾病活动度[系统性红斑狼疮疾病活动度指数2000(SLEDAI-2000)、抗双链DNA(抗dsDNA)抗体]的关系。结果 SLE组血清IL-33、sST2水平均明显高于正常对照组(P<0.01)。Spearman相关分析结果显示,SLE患儿血清IL-33、sST2水平与SLEDAI-2000评分均呈正相关(r值分别为0.399、0.502,P值分别为0.024、0.003),与抗dsDNA抗体滴度也均呈正相关(r值分别为0.395、0.529,P值分别为0.025、0.002)。结论 IL-33、sST2可能在儿童SLE的发病过程中起重要作用。

Objective To investigate the expressions and roles of serum interleukin 33(IL-33)and soluble suppression of tumorigenicity 2(sST2) in children with systemic lupus erythematosus(SLE). Methods Serum levels of IL-33 and sST2 in 32 children with SLE(SLE group) and 50 healthy children(healthy control group) were determined by enzyme-linked immunosorbent assay(ELISA). The correlations between IL-33,sST2 and systemic lupus erythematosus disease activity index 2000(SLEDAI-2000),anti-double-stranded DNA(anti-dsDNA) antibody were evaluated. Results Serum levels of IL-33 and sST2 were higher in SLE group than those in healthy control group(P<0.01). Spearman correlation analysis showed that serum levels of IL-33 and sST2 in children with SLE were positively correlated with SLEDAI-2000(r=0.399 and 0.502,P=0.024 and 0.003,respectively). Serum levels of IL-33 and sST2 in children with SLE were positively correlated with anti-dsDNA antibody(r=0.395 and 0.529,P=0.025 and 0.002,respectively). Conclusions Serum IL-33 and sST2 may play roles in the pathogenesis of SLE among children.