摘要
转铁蛋白是血清中浓度较高的糖蛋白之一。由于其特殊的生理功能,转铁蛋白一直受到国内外研究者的关注。随着对转铁蛋白功能、结构研究的不断深入,其抗菌活性、营养细胞、促进生长分化等功能逐渐被揭示。转铁蛋白已被广泛用于铁代谢相关疾病的诊断,与肝脏的病理生理状态也有着密切的关系。近年来,随着糖组学研究的不断深入和相关检测技术的发展,学者们在多种疾病中发现了转铁蛋白糖基化修饰的异常,尤其是在肿瘤状态下的改变更为明显。文章对转铁蛋白及其糖基化改变与疾病的关系及在疾病诊断中应用作一综述。
Transferrin is one of high abundance glycoproteins in serum,which has become the research focus because of its special physiological function. Its multiple functions include antimicrobial activity,nourishing cells,growth and differentiation activities as the researches of its function and structure deepened. Transferrin determination has been widely used in the diagnostic evaluation of iron-related disorders. There is a close relationship with the pathophysiologic state of the liver as well. Recently,altered glycosylation of transferrin has been recognized in a variety of diseases,especially in malignancies as with the achievement of glycomics and related technologies. In this review,transferrin and its altered glycosylation as well as its relationship with diseases are introduced.
作者
关雯倩
高春芳
GUAN Wenqian;GAO Chunfang(Department of Laboratory Diagnosis,Eastern Hepatobiliary Surgery Hospital,Shanghai 200438,China)
出处
《检验医学》
CAS
2019年第6期563-566,共4页
Laboratory Medicine
基金
上海市科学技术委员会项目(15JC1404100、17JC1404500、17411960500)
关键词
转铁蛋白
糖蛋白
糖基化
Transferrin
Glycoprotein
Glycosylation
