妥乐平联合阿昔洛韦治疗白内障超声乳化术后并发角膜炎疗效分析

Efficacy analysis of trolocin combined with acyclovir in the treatment of keratitis after phacoemulsification

目的 探究妥乐平联合阿昔洛韦治疗白内障超声乳化术后并发角膜炎疗效。方法 选取我院眼科2015年1月至2018年12月收治的80例(112眼)行超声乳化术治疗的白内障患者作为研究对象,采用随机分组法,将全部患者分为对照组和观察组,每组各40例。对照组采用常规治疗,包括阿昔洛韦注射液、阿昔洛韦滴眼液、更昔洛韦眼用凝胶、左氧氟沙星滴眼液等治疗,观察组在对照组的基础上采用神经妥乐平注射液静脉滴注治疗,比较两组临床治疗效果、不良反应和复发情况。结果 对照组临床治疗总有效率为75.00%(30/40),观察组临床治疗总有效率为92.50%(37/40),观察组高于对照组,差异有统计学意义(P<0.05)。对照组不良反应发生率为17.50%(7/40),复发率为20.00%(8/40);观察组不良反应发生率为15.00%(6/40),复发率为5.00%(2/40),观察组不良反应发生率与对照组差异无统计学意义(P>0.05),复发率低于对照组,差异有统计学意义(P<0.05)。结论 采取神经妥乐平注射液联合阿昔洛韦注射液治疗方案疗效显著,安全性高、复发率低;白内障超声乳化术后可在一定程度上减少角膜炎的发生,要求临床采取积极的预防性措施,从而提升超声乳化术的治疗效果,促进患者的健康恢复。

Objective To investigate the efficacy of tolapline combined with acyclovir in the treatment of keratitis after phacoemulsification. Methods Eighty patients (112 eyes) who underwent phacoemulsification treated with phacoemulsification from January 2015 to December 2018 in our hospital were selected as subjects.All patients were divided into control group and observation group by digital random grouping,40 cases in each group.The control group received conventional treatment,including acyclovir injection,acyclovir eye drops,ganciclovir ophthalmic gel,levofloxacin eye drops,etc.,and the observation group was treated with intravenous infusion of neurotropin injection on the basis of the control group.The clinical treatment effects,adverse reactions and recurrence were compared between the two groups. Results The total effective rate of clinical treatment in the control group was 75.00%(30/40),and that in the observation group was 92.50%(37/40),which was higher than that in the control group ( P <0.05).The incidence of adverse reactions in the control group was 17.50%(7/40),and the recurrence rate was 20.00%(8/40);in the observation group,the incidence of adverse reactions was 15.00%(6/40),and the recurrence rate was 5.00%(2/40).There was no significant difference in the incidence of adverse reactions between the observation group and the control group ( P >0.05),and the recurrence rate was lower than that of the control group ( P <0.05). Conclusion The treatment with neurotropin injection combined with acyclovir injection has significant efficacy,high safety and low recurrence rate.Phacoemulsification can reduce the incidence of keratitis to some extent,and requires active preventive measures to improve the therapeutic effect of phacoemulsification and promote the recovery of patients' health.