唾液酸结合免疫球蛋白样凝集素-9在多种疾病中作用机制的研究进展

Research Progress on the Role of Sialic Acid-binding Immunoglobulin-like Lectin 9 in Various Diseases

唾液酸结合免疫球蛋白样凝集素9(sialic acid-binding immunoglobulin-like lectin 9,Siglec-9)是表达于免疫细胞表面并能识别含特定唾液酸配体的受体,在机体免疫应答过程中发挥重要作用。在感染性疾病、自身免疫性疾病及癌症中,均有报道Siglec-9的表达增加。病原微生物和肿瘤细胞可通过上调自身特定的唾液酸配体与宿主免疫细胞表面的Siglec-9结合从而抑制免疫细胞的识别和杀伤作用,并抑制促炎细胞因子和促进抑炎细胞因子的释放,最终导致免疫抑制、肿瘤免疫逃逸等。而Siglec-9的免疫抑制功能对中性粒细胞增多型哮喘、自身免疫性疾病等疾病可能是有利的。所以进一步研究Siglec-9的作用机制具有重要意义。

Sialic acid-binding immunoglobulin-like lectin 9( Siglec-9) is a receptor that expresses on the surface of immune cells. It plays an important role in the body’s immune response. Increased expression of Siglec-9 has been reported in infectious diseases,autoimmune diseases and cancer. Pathogenic microorganism and tumor cells can inhibit the recognition and killing of immune cells by upregulating their own specific sialic acid and binding with Siglec-9 on the surface of host immune cells,and suppress the release of pro-inflammatory cytokines and promote the release of anti-inflammatory cytokines,eventually leading to immunosuppression,tumor immune escape and the like. However,the immunosuppressive function of Siglec-9 may be advantageous for diseases such as neutrophil asthma and autoimmune diseases. Therefore,further research on the mechanism of action of Siglec-9 is of great significance.