文拉法辛治疗抑郁症的疗效和安全性分析

Efficacy and safety of venlafaxine in the treatment of depression

目的分析文拉法辛治疗抑郁症的疗效和安全性。方法选取本院2015年1月至2017年12月收治的抑郁症患者100例作为本次研究的对象,通过数字表随机法将其分为观察组(50例)和对照组(50例)。采用舍曲林治疗对照组,采用文拉法辛治疗观察组。比较两组治疗前后HAMD评分情况、治疗效果、显效时间以及不良反应。结果在HAMD评分方面,两组治疗前比较差异无统计学意义;而治疗后2周、4周、8周观察组较对照组均明显下降,组间对比差异具有统计学意义(P<0.05)。在治疗效果方面,观察组总有效率96.0%较对照组82.0%明显较高,组间对比差异具有统计学意义(P<0.05)。在显效时间方面,观察组治疗1周、2周后的显效率分别为22.0%、86.0%较对照组0.0%、50.0%均明显较高,组间对比差异具有统计学意义(P<0.05)。在不良反应方面,观察组主要为食欲减退、便秘、血压升高、头昏等,而对照组主要为恶心呕吐、便秘、口干口苦等,观察组总发生率8.0%较对照组22.0%明显较低,组间对比差异具有统计学意义(P<0.05)。结论文拉法辛治疗抑郁症的疗效显著,既能快速、有效的改善患者抑郁症状,还能减少各种不良反应,因而安全性较高,值得临床应用推广。

Objective To analyze the efficacy and safety of venlafaxine in the treatment of depression.Methods 100 patients with depression from January 2015 to December 2017 were randomly divided into observation group(n=50)and control group(n=50).Sertraline was used as control group and venlafaxine as observation group.Before and after treatment,the HAMD score,therapeutic effect,effective time and adverse reaction were compared between the two groups.Results In the HAMD score,there was no significant difference between the two groups before treatment;the 2 weeks,4 weeks,8 weeks observation group was significantly lower than the control group after treatment,and the difference between the groups was statistically significant(P<0.05).The total effective rate of the observation group was 96.0%,which was significantly higher than that of the control group(82.0%),and the difference between the two groups was significant(P<0.05).In terms of effective time,the effective rates of the observation group after treatment for 1 week and 2 weeks were 22.0%and 86.0%,were significantly higher than the control group 0.0%and 50.0%,and the difference between the groups was statistically significant(P<0.05).The main adverse reactions in the observation group were loss of appetite,constipation,elevated blood pressure,and dizziness.The adverse reactions in the control group were mainly nausea and vomiting,constipation,dry mouth and mouth pain.The total incidence of the observation group was 8.0%,which was lower than that of the control group(22.0%),the difference between groups was statistically significant(P<0.05).Conclusion Venlafaxine is effective in the treatment of depression.It can improve depressive symptoms quickly and effectively,and reduce all kinds of adverse reactions.Therefore,it is safe and worthy of clinical application.