膝骨关节炎与外周血IL-4、IL-6、IL-17A的相关性分析

Analysis of the Correlation Between Knee Osteoarthritis and IL-4,IL-6 and IL-17A in Peripheral Blood

目的:比较膝骨关节炎患者及健康人群外周血中白细胞介素(IL)-4、IL-6、IL-17A的含量,研究IL-4、IL-6、IL-17A与膝骨关节炎严重程度的关系,探讨膝骨关节炎的发病机制.方法:选取膝骨关节炎患者67例为膝骨关节炎组,再选取同期体检的健康志愿者58例为健康对照组.检测2组外周血中IL-4、IL-6、IL-17A的水平,使用Lequesne指数评估骨关节炎的严重程度.结果:膝骨关节炎组外周血中IL-6、IL-17A含量较健康对照组高,差异有统计学意义(P<0.05),IL-4水平与健康对照组比较,差异无统计学意义(P>0.05);膝骨关节炎组外周血中IL-6、IL-17A的水平与膝骨关节炎的严重程度呈正相关(r=0.734,P<0.01;r=0.463,P<0.05).结论:膝骨关节炎患者外周血中IL-6、IL-17A的表达明显升高,并且与病变严重程度呈正相关,IL-6、IL-17A可能参与了膝骨关节炎的病理过程,阻断IL-6、IL-17A信号通路,有望减轻及改善患者膝关节的破坏.

Objective:To compare the levels of IL-4,IL-6 and IL-17A in peripheral blood of patients with knee osteoarthritis and healthy people,to study the relationship between the levels of IL-4,IL-6 and IL-17A and the severity of knee osteoarthritis,and to explore the pathogenesis of knee osteoarthritis.Methods: Sixty-seven patients with knee osteoarthritis were selected as the knee osteoarthritis group,and 58 healthy volunteers were selected as the healthy control group.The levels of IL-4,IL-6 and IL-17A in peripheral blood of the two groups were detected,and the severity of osteoarthritis was assessed by Lequesne index.Results:The levels of IL-6 and IL-17A in the peripheral blood of the knee osteoarthritis group were higher than those of the healthy control group,with a statistical significance(P < 0.05).There was no significant difference in the levels of IL-4 between the knee osteoarthritis group and the healthy control group(P > 0.05).The levels of IL-6 and IL-17A in peripheral blood of the knee osteoarthritis group were positively correlated with the severity of knee osteoarthritis (r = 0.734,P < 0.01;r = 0.463,P < 0.05).Conclusion:The expression of IL-6 and IL-17A in the peripheral blood of patients with knee osteoarthritis is significantly increased and positively correlated with the severity of the disease.IL-6 and IL-17A may be involved in the pathological process of knee osteoarthritis.Blocking IL-6 and IL-17A signaling pathways is expected to reduce and improve the damage of knee joint.