替考拉宁在特殊人群中药动学研究进展

Advances in research on pharmacokinetics of teicoplanin in special populations

替考拉宁是临床治疗耐甲氧西林金黄色葡萄球菌等耐药革兰阳性菌感染的首选药物之一。本文分别对近年来替考拉宁在老年人、儿童,重症感染、肾功能不全、低白蛋白血症、严重烧伤、血液肿瘤患者等特殊人群中的药动学研宂进展进行综述,考察特殊病理生理状态对其疗效和安全性的影响,为临床合理用药提供参考。

Teicoplanin is one of the first optional drugs in the clinical treatment of drug-resistant Grampositive bacteria infections (such as methicillin-resistant Staphylococcus aureus, etc.). This paper reviewed recent advances in pharmacokinetics of teicoplanin in special populations of the elderly, children, severe infections, renal dysfunction, hypoalbuminemia, severe bums and hematological malignancies and investigated the effect of special pathophysiological states on their efficacy ansd safety, in order to provide reference on the rational use of antibiotics.