脂肪细胞因子与老年骨密度的相关性

Correlation between adipocytokines and bone density in elderly

[目的]研究老年骨质疏松症患者脂肪细胞因子与骨密度的相关性。[方法]对180例受检者进行骨密度测定,根据骨密度测量T值分为骨质疏松组、骨量减少组各70例,骨量正常组即健康受检者40例,采用酶联免疫法检测受检者血清瘦素(leptin)、抵抗素(resistin)、脂联素(adiponectin)、内脂素(visfatin)、网膜素-1(omentin-1)和内源性配体(apelin)水平。[结果]三组血清Visfatin因子表达水平比较差异无统计学意义(P>0.05);而Leptin、Resistin、Adiponectin、Omentin-1、Apelin组间差异有统计学意义(P<0.01)。Pearson线性回归分析结果显示:腰椎骨密度与Leptin(B=0.145,P=0.044)呈线性正相关,与Resistin(B=-0.020,P=0.004)、Adiponectin(B=-0.031,P=0.008)、Omentin-1(B=-0.030,P=0.001)呈线性负相关。[结论]脂代谢异常可能与骨质疏松有关,提示脂肪细胞相关因子的异常表达对老年骨质疏松症的发病有一定的影响。

[Objective] To explore the correlation between adipocytokines and bone density in elderly.[Methods] Based on T value of bone mineral density measured, 180 patients were divided into the osteoporosis group and the bone mass decreased group with 70 cases in each group, additionally 40 healthy subjects with normal bone mass were also enrolled into this study. The serum adipocytokines, including leptin, resistin, adiponectin, visfatin, omentin-1 and apelin were measured by ELISA.[Results] Although there was no significant difference in the visfatin among the three groups (P>0.05), the leptin, resistin, adiponectin, om entin-1 and apelin were statistically significant among them (P<0.05). In term of Pearson correlation analysis, the lumbar bone mineral density proved significantly positively correlated to the leptin (B=0.145, P=0.044), whereas negatively correlated to the resistin (B=-0.020, P=0.004), adiponectin (B=-0.031, P=0.008), and omtin-1 (B=-0.030, P=0.001).[Conclusion] The abnormal lipid metabolism might be related to osteoporosis, which implies that the abnormal expression of fat cell related factors has a certain impact on the incidence of osteoporosis in the elderly.