基于文献分析中医药治疗溃疡性结肠炎用药规律

Literature Base Study on the Law of Chinese Medicine on Ulcerative Colitis

目的通过文献挖掘探讨中医药治疗溃疡性结肠炎(UC)的用药规律。方法系统检索CNKI数据库近10年来的相关文献,将符合纳入标准和排除标准的137篇不同分期的溃疡性结肠炎的中医治疗文献中的用药和药物归类,分别查出其性、味、归经,并用SPSS21.0软件进行统计分析。结果 UC活动期以性寒凉、味苦甘辛入脾胃经、肺大肠、肝胆经的清热、补虚、理气、止血药为主,常用药如黄连、黄芩等;缓解期以性温热、味苦甘辛入脾胃经、肺大肠、肝胆经的补虚、理气、温里、收涩药为主,常用药如白术、白芍等。结论中医药治疗UC的药性在活动期以寒凉为主,在缓解期以温热为主,药味以苦、甘、辛为主,归经以脾胃经、肺大肠、肝胆经为主,调脾胃、祛邪实、理气机为治疗本病的一个重要治则,尤重清法和补法的应用。

objective: To study the regularity and characteristics of common drug application and normality of ulcerative colitis based on literature, and provide reference for the clinical treatment of ulcerative colitis. Methods: System for 10 years literature retrieval CNKI database, will be in conformity with the inclusion criteria and exclusion criteria, 137 articles in the literature of traditional Chinese medicine treatment of ulcerative colitis drug use and drug category, and find out its sex, taste and return the respectively,using SPSS 21.0 software for statistical analysis. Results: The active period of UC, which common nature of medicinal was cold, the common flavors of medicinal were bitter, sweet, acrid. The common channel tropisms were spleen channel, stomach channel, lung channel, large intestine channel, liver channel, gallbladder channel. The commonly used oral medicines were heat-clearing medicinal,deficiency-supplementing medicinal, Qi-rectifying medicina, blood-stanching medicinal. The most use of medicines were rhizoma coptidis, rhizoma coptidis and so on. The remission period of UC, which common nature of medicinal was warm, the common flavors of medicinal were bitter, sweet, acrid. The common channel tropisms were spleen channel, stomach channel, lung channel, large intestine channel, liver channel, gallbladder channel. The commonly used oral medicines were deficiency-supplementing medicinal, Qi-rectifying medicina, interior warming medicinal, astringing medicinal. The most use of medicines were Radix paeoniae alba, radix paeoniae alba and so on. Conclusions: Chinese medicine for ulcerative colitis is mainly cold in active stage and warm in remission stage. The common flavors of medicinal were bitter, sweet, acrid. The common channel tropisms were spleen channel, stomach channel, lung channel, large intestine channel, liver channel, gallbladder channel. Regulating spleen and stomach, dispelling pathogenic factors and regulating Qi-movement is an important principle for the treatment of this disease, especially the application of Clearing method and Tonifying method.