9.4 T超高分辨活体猴脑磁化率成像研究

Quantitative susceptibility mapping of ultra-high resolution monkey brain in vivo at 9.4 T

定量磁化率成像(QSM)可以提供组织的磁化率信息,在临床诊断和研究中有重要价值。目前9.4T下高分辨活体猴脑QSM工作尚未见报道。本研究获得了9.4T200μm各向同性的超高分辨率活体猴脑QSM成像,并发现在超高分辨磁共振图像中,QSM固有的奇点问题会在L2正则化处理中严重发散。本文引入了k空间阈值分割法来消除图像伪影,并发现当阈值在0.2到0.3的区间内图像重建效果最佳。高分辨率活体猴脑QSM可为相关脑科学研究提供一种新的手段。

Quantitative susceptibility mapping(QSM)can provide tissue susceptibility information and has been adapted for clinical research and diagnosis.QSM of monkey brain in vivo at 9.4 T has not been demonstrated so far.In this study 9.4 T in vivo monkey brain QSM was performed with 200μm isotropic high-resolution.It was found that the inherent singularity problem for QSM diverged significantly at ultra-high image resolution during regularization process and resulted in severe image artifacts.The K-space division(TKD)was applied to eliminate the artifacts,with an optimal threshold level between 0.2 and 0.3.High resolution QSM of monkey brain in vivo can thus provide a novel tool for brain research.