清热化痰法联合阿奇霉素治疗小儿肺炎支原体感染的支气管炎临床疗效研究

Clinical Efficacy of Clearing Heat and Resolving Phlegm Combined with Azithromycin in the treatment of Bronchitis Caused by Mycoplasma Pneumoniae Infection in Children

目的分析出现肺炎支原体感染的支气管炎小儿临床应用中药清热化痰法联合西药阿奇霉素治疗的效果。方法方便选择2016年2月—2018年7月该院小儿肺炎支原体感染的支气管炎123例为对象,其中61例接受单一阿奇霉素治疗,视作对照组,另外62例接受清热化痰法联合阿奇霉素治疗,视作观察组,比较两组效果。结果观察组总有效率为90.32%,高于对照组73.77%(χ^2=5.7357,P=0.0166);观察组治疗后咳嗽消除、高热消退、肺部体征恢复、肺部阴影消失时间短于对照组(t=5.0631、9.8016、9.8207、5.2364,P=0.0000);观察组治疗后IL-6、TNF-α、CRP水平均低于对照组(P<0.05)。结论小儿肺炎支原体感染的支气管炎临床治疗中选择清热化痰法联合阿奇霉素能够更迅速改善临床症状,加快患儿恢复,值得推广。

Objective To analyze the clinical effect of traditional Chinese medicine Qingre Huatan method combined with western medicine Azithromycin in the treatment of bronchitis with Mycoplasma pneumoniae infection in children.Methods A total of 123 cases of bronchitis caused by Mycoplasma pneumoniae infection in children in our hospital from February2016 to July 2018 were convenient selected as subjects.The control group(n=61)cases single azithromycin treatment as,and the observation group(n=62)received heat-clearing and phlegm-resolving therapy combined with azithromycin treatment.The effects of the two groups were compared.Results The total effective rate of the observation group was 90.32%,which was higher than that of the control group(73.77%)(χ^2=5.735 7,P=0.016 6).The time of cough elimination,fever subsidence,recovery of pulmonary signs and disappearance of pulmonary shadow in the observation group was shorter than those in the control group(t=5.063 1,9.801 6,9.820 7,5.236 4,P=0.000 0).The levels of IL-6,TNF-a and CRP in the observation group were higher than those in the control group(P<0.05).Conclusion The method of clearing heat and resolving phlegm combined with azithromycin can improve clinical symptoms more quickly and accelerate recovery of children with bronchitis caused by Mycoplasma pneumoniae infection,which is worthy of promotion.