前列地尔联合黄芪对重度全身性感染伴急性肾损伤的疗效分析

The Apeutic Effect of Alprostadil Combined with Astragalus on Acute Kidney Injury in Systemic Infection

目的:探讨前列地尔联合黄芪治疗重度全身性感染伴急性肾损伤的效果。方法:选取2012年6月-2017年6月医院收治的重度全身性感染伴急性肾损伤患者120例,根据治疗方式分为研究组和对照组,各60例。对照组采用常规治疗,研究组在对照组基础上加用前列地尔联合黄芪治疗,疗程均为2周。比较两组治疗前后器官功能衰竭评分(SOFA)、急性生理与慢性健康评分(APACHEⅡ)以及急性炎症指标。结果:治疗后,两组SOFA评分和APACHEⅡ评分均低于治疗前(P<0.05),且研究组治疗后SOFA评分和APACHEⅡ评分均明显低于对照组(P<0.05)。两组治疗后PCT、CRP、TNF-α和IL-6水平均明显低于治疗前(P<0.05),且研究组治疗后PCT、CRP、TNF-α、IL-6水平均明显低于对照组(P<0.05)。结论:前列地尔联合黄芪对重度全身性感染患者急性肾损伤治疗效果较好,可有效改善患者临床评分,降低炎症介质水平,临床疗效优于单纯基础治疗方案。

Objective:To investigate the effect of Alprostadil combined with Astragalus on clinical outcomes in patients with severe systemic infection with acute kidney injury.Method:120 patients with severe systemic infection and acute kidney injury admitted to hospital from June 2012 to June 2017 were selected and divided into study group and control groups,60 cases in each groups.The control group was treated with conventional therapy.The study group was treated with Alprostadil combined with Astragalus on the basis of the control group,the course of treatment was 2 weeks.The infection-related organ failure score(SOFA),acute physiology and chronic health score(APACHEⅡ)and acute inflammation indicators in two groups were compared before and after treatment.Result:The SOFA score and APACHEⅡscore of two groups after treatment were lower than those before treatment(P<0.05).The SOFA score and APACHEⅡscore after treatment in the study group were significantly lower than those in control group(P<0.05).The levels of PCT,CRP,TNF-αand IL-6 in the two groups were significantly lower than those before treatment(P<0.05).The levels of PCT,CRP,TNF-αand IL-6 in the study group after treatment were significantly lower than those of the control group(P<0.05).Conclusion:Alprostadil combined with Astragalus is effective in the treatment of acute kidney injury in patients with severe systemic infection,it can effectively improve the clinical score and reduce the level of inflammatory mediators,the clinical efficacy is better than the simple basic treatment.