小剂量米氮平与地西泮改善失眠患者生活质量的对比研究

Comparative Study of Low-dosage Mirtazapine and Diazepam on Life Quality for Insomnia Patients

目的:小剂量米氮平与地西泮改善失眠患者生活质量的效果对比。方法:以本院2016年2月-2018年2月收治的80例失眠患者为研究对象,随机分成观察组(小剂量米氮平治疗)与对照组(地西泮治疗),各40例。比较不同治疗方法对治疗效果的影响。结果:观察组治疗总有效率(92.50%)明显高于对照组(75.00%),差异有统计学意义(P<0.05)。治疗后观察组SF-36各维度评分均高于对照组(P<0.05),观察组不良反应发生率(67.50%)与对照组(70.00%)比较,差异无统计学意义(P>0.05)。结论:将小剂量米氮平应用于失眠患者,可显著提升睡眠质量,且不良反应可自行消除,生活质量高,此方法值得应用与推广。

Objective:To compare the effect of low-dosage Mirtazapine and Diazepam on the life quality for insomnia patients.Method:80 insomnia patients treated from February 2016 to February 2018 in our hospital were randomly divided to observation group(treated with low-dosage Mirtazapine)and control group(treated with Diazepam),40 cases in each group.The effects of different treatments were compared.Result:The total effective rate in the observation group(92.50%)was significantly higher than that in the control group(75.00%),the difference was statistically significant(P<0.05).After treatment,the SF-36 scores of the observation group in all dimensions were higher than those of the control group(P<0.05).The adverse event rate between observation group(67.50%)and control group(70.00%)was not significantly different(P>0.05).Conclusion:The application of low-dosage Mirtazapine in patients with insomnia can significantly improve the quality of sleep,and adverse reactions can be eliminated by themselves,the quality of life is high.This method is worthy of application and promotion.