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脑电治疗联合多巴丝肼对帕金森病运动症状的影响 被引量:1

Effect of Electroencephalogram Combined with Levodopaand Benserazide Hydrochlo-ride on Motor Symptoms of Parkinson’s Disease
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摘要 目的观察脑电治疗联合多巴丝肼治疗帕金森病运动症状的效果及安全性。方法将2017年10月~2018年12月我院神经内科收治的临床确诊为帕金森病的60例患者随机分为干预组(30例)和对照组(30例)。对照组给予多巴丝肼连续治疗4周;干预组在多巴丝肼治疗基础上给予脑电治疗4周,每周5次,共20次。采用帕金森病综合评定量化表评估两组患者治疗前后的运动能力。比较两组治疗前后的临床疗效、运动能力评分及不良反应情况。结果干预组临床总有效率为90.0%(27/30),高于对照组的76.7%(23/30)(χ^2=8.027,P<0.01)。两组治疗2、4周后的运动能力评分均明显低于治疗前(P<0.05);干预组治疗4周后运动能力评分低于对照组(P<0.05)。两组均未出现严重不良反应。结论脑电治疗联合多巴丝肼治疗帕金森病效果显著,可改善患者的运动症状,且安全性较高。 Objective To observe the efficacy and safety of electroencephalogram (EEG) combined with Levodopaand Benserazide Hydrochlo-ride in the treatment of motor symptoms of Parkinson's disease.Methods 60 patients with Parkinson's disease in neurology department admitted to our hospital from October 2017 to December 2018 were randomly divided into intervention group and control group with 30 cases in each group.The patients in control group were treated with Levodopaand Benserazide Hydrochlo-ride for 4 weeks.The patients in intervention group were treated with electroencephalogram for 4 weeks on the basis of continuous Levodopaand Benserazide Hydrochlo-ride,5 times a week,20 times a week for 4 weeks.The athletic ability of two groups were evaluated by the Parkinson's Disease Score III before and after treatment.Results The total effective rate of the intervention group was 90%(27/30),which was higher than 76.7%(23/30) of the control group (χ^2 =8.027,P <0.01).The exercise ability scores of the two groups after 2 and 4 weeks of treatment were significantly lower than before treatment ( P <0.05);the exercise ability scores of the intervention group after 4 weeks of treatment were lower than the control group ( P <0.05).No serious adverse reactions occurred in either group.Conclusion EEG therapy combined with Levodopaand Benserazide Hydrochlo-ride in the treatment of Parkinson's disease is effective,which can improve the motor symptoms of Parkinson patients,and also have high safety.
作者 张林艳 陈海亮 林国吉 陈杰 ZHANG Lin-yan;CHEN Hai-liang;LIN Guo-ji;CHEN Jie(Department of Neurology,Fujian Fuzhou Neuropsychological Hospital,Fuzhou Gity,Fujian Province,350008,China)
出处 《蛇志》 2019年第2期202-203,219,共3页 Journal of Snake
基金 福州市卫生计生科技计划项目(项目名称:脑电治疗、中频脉冲电治疗对改善帕金森病运动症状的影响 项目编号:2017-S-wq39)
关键词 帕金森病 运动症状 脑电治疗 多巴丝肼 帕金森病综合评分 Parkinson's disease Motor symptoms Electroencephalogram therapy Levodopaand Benserazide Hydrochlo-ride Comprehensive score of Parkinson's disease
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