小剂量激素联合环磷酰胺治疗系统性红斑狼疮的临床研究

Clinical Research of Low-dosage Hormone Combined with Cyclophosphamide in the Treatment of Systemic Lupus Erythematosus

目的探讨小剂量激素联合环磷酰胺治疗系统性红斑狼疮(SLE)的临床疗效。方法选取2016年12月~2018年6月我院收治的60例SLE患者,按随机数字表法分为观察组和对照组,每组各30例。观察组给予小剂量激素结合环磷酰胺治疗,对照组给予小剂量激素。比较两组总有效率、血肌酐、补体及白蛋白水平。结果观察组总有效率为93.33%(28/30),明显高于对照组的36.67%(11/30)(χ^2=70.557,P<0.05)。两组血肌酐、补体及白蛋白水平比较,差异有统计学意义(t=4.408、4.708、2.486,P<0.05)。结论在SLE患者中给予小剂量激素结合环磷酰胺治疗效果较好,值得今后广泛推广应用。

Objective To investigate the clinical efficacy of low-dose hormone combined with cyclophosphamide in the treatment of systemic lupus erythematosus (SLE).Methods 60 SLE patients admitted to our hospital from December 2016 to June 2018 were enrolled and randomly divided into observation group and control group,30 cases in each group.The observation group was treated with low-dosage Hormone combined with Cyclophosphamide;the control group was treated with low-dosage Hormone.The total effective rate,the level of serum creatinine,alexin and albumin were compared between the two groups.Results The total effective rate in the observation group was 93.33%(28/30),which was significantly higher than that in control group [36.67%(11/30)](χ^2 =70.557,P <0.05).There was a statistically significant differences in serum creatinine,alexin and albumin levels between two groups ( t =4.408,4.708,2.486,P <0.05).Conclusion The low-dose hormone combined with cyclophosphamide is effective in the treatment of SLE patients and worthy of extensive application in the future.