雷公藤在银屑病治疗中的应用

Application of Tripterygium Wilfordii in the Treatment of Psoriasis

目的为雷公藤在银屑病治疗中的应用提供参考。方法以"雷公藤""药理作用","雷公藤""银屑病","Tripterygium wilfordii""psoriasis""pharmacological effects"等为关键词,组合检索2008年1月至2018年1月在PubMed、中国知网、万方等数据库中的相关文献,对雷公藤在银屑病治疗中的应用进行综述。结果与结论共检索相关文献573篇,其中有效文献44篇。雷公藤具有显著的抗炎、抗肿瘤、调节免疫等功效。银屑病为常见免疫功能紊乱所致慢性炎症性皮肤病。大量临床研究证明,雷公藤单用或联用其他药物对各类型银屑病均有疗效,但雷公藤本身毒性较大,应用时需谨慎。

Objective To provide reference for the application of Tripterygium wilfordii in the treatment of psoriasis.Methods With″Tripterygium wilfordii and pharmacological effects″″Tripterygium wilfordii and psoriasis″″Tripterygium wilfordii″″psoriasis″and″pharmacological effects″as the keywords,the relevant literature in the database of PubMed,CIKN,Wanfang and so on from January 2000 to January 2018 were retrieved.The application of Tripterygium wilfordii in the treatment of psoriasis was reviewed.Results and Conclusion A total of 573 relevant documents were retrieved,of which 44 documents were valid.Tripterygium wilfordii has significant anti-inflammatory,anti-tumor,immune regulation and other effects.Psoriasis is a common chronic inflammatory skin disease induced by immune dysfunction.A large number of clinical studies have proven that Tripterygium wilfordii alone or in combination with other drugs are effective for all types of psoriasis.However,Tripterygium wilfordii is highly toxic,which should be used with caution.