缺血性心肌病与能量代谢研究进展

Research progress on ischemic heart disease and energy metabolism

缺血性心肌病伴随着心脏能量代谢的变化,这些变化主要为脂肪酸氧化速率增加和/或葡萄糖氧化途径中糖酵解减少.通过减少脂肪酸氧化或者增加葡萄糖氧化的方式干预能量代谢,能够改善缺血性心肌病的病理变化和心脏功能.随着代谢组学检测技术的发展,针对缺血性心肌病进行早期代谢产物检测手段和机制探索方式更加多样,丰富了目前对缺血性心肌病代谢变化的认知.同时,了解并分析缺血性心肌病的代谢变化能为缺血性心肌病的创新药物研发提供新线索.系统介绍了缺血性心肌病中三大营养物质能量代谢变化,干预不同能量变化在心脏功能障碍中的作用,并探讨通过代谢手段治疗缺血性心脏疾病的可能性.

Ischemia heart disease is often accompanied by cardiac energy metabolism,which is reflected in contractile dysfunction and a decrease in cardiac e?ciency. Specific metabolic changes include a relative increase in cardiac fatty acid oxidation rates and an uncoupling of glycolysis from glucose oxidation. Recent evidence suggests that therapeutically regulating cardiac energy metabolism by reducing fatty acid oxidation and/or increasing glucose oxidation can improve cardiac function of the ischemic heart. With the development of metabolomics technology, the detection methods and mechanisms of early metabolites for ischemic cardiomyopathy are further explored. This paper first discusses systematically the change of energy metabolic which contributes to cardiac dysfunction,and then it explores the potential for targeting treatment ischemic heart disease through metabolic pathway.