运动诱导生理性心肌肥厚的非编码RNA调节机制

Non-coding RNAs in exercise-induced cardiac hypertrophy

大量研究表明运动训练对心脏具有保护作用.运动可诱导生理性心肌肥厚,对于心力衰竭具有保护作用.心肌肥厚可分为生理性和病理性心肌肥厚,后者可导致心脏功能受损、心力衰竭以及高死亡率.近几十年来,非编码RNA 包括微小RNA (microRNA, miRNAs)、长链非编码RNA (long noncodingRNA, lncRNAs)和环状RNA (circularRNA, circRNAs)等,引起了研究者的极大关注,非编码RNA 的失调被证实与多种心血管疾病密切相关.综述了心肌肥厚,尤其是生理性心肌肥厚中miRNAs, lncRNAs和circRNAs的特征、功能和分子机制.同向调控这些运动影响的非编码RNA 可以防治心力衰竭.

Increasing evidence supports the protective role of exercise training in preventing cardiovascular diseases. Exercise induces physiological cardiac growth, and thus protects the heart against pathological remodeling and heart failure. Cardiac hypertrophy falls into two types, namely, the physiological cardiac hypertrophy and the pathological cardiac hypertrophy, and the latter can result in impaired cardiac functioning, heart failure and is predictive of a higher incidence of death due to cardiovascular diseases. Non-coding RNAs (ncRNAs) including microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) have drawn significant attention over the last couple of decades, and their dysregulation is increasingly being linked to many cardiovascular diseases. In this paper, the profiling function, and molecular mechanism of miRNAs, lncRNAs, and circ- RNAs in cardiac hypertrophy, especially in physiological hypertrophy have been analyzed. Targeting these ncRNAs represents novel therapy for heart failure.