HPV不同亚型在宫颈癌前病变及宫颈癌中的分布情况

Distribution of HPV subtype in cervical precancerous lesions and cervical cancer

目的:探讨HPV不同亚型在宫颈癌前病变及宫颈癌中的分布情况。方法:选取我院于2015年1月至2017年1月期间收治的124例宫颈癌患者和宫颈癌前病变患者,其中宫颈癌患者有36例,宫颈癌前病变患者有88例。对所有入选患者的宫颈脱落细胞进行采集,并且进行人乳头瘤病毒检测,观察分析HPV不同亚型在宫颈癌前病变及宫颈癌中的分布情况。结果:共有89例(71.77%)患者检测出HPV阳性,其中宫颈癌患者的阳性检出率为100%,显著高于癌前病变患者中的阳性检出率60.23%(P<0.05)。宫颈癌患者中HPV18和HPV16亚型的感染率最高,分别为44.44%和47.22%;在88例宫颈癌前病变患者中,低级别型患者的HPV33和HPV52、HPV16亚型感染率最高,分别为9.68%和32.36%、32.36%;高级别型患者的HPV58、HPV52、HPV18、HPV16亚型感染率最高,分别为13.64%、13.64%、22.73%、31.82%。89例HPV感染患者中有9例患者出现多重感染,多重感染率为10.11%,其中三重及以上感染率为3.37%。所有宫颈癌HPV感染患者均为单一感染;癌前病变患者中低级别多重感染率为9.68%,高级别多重感染率为27.27%。结论:宫颈癌患者和宫颈癌前病变患者中均以HPV16和HPV18亚型感染率较高,此外宫颈癌前病变患者中的HPV58和HPV52亚型患者也具有较高的感染率;临床上使用HPV感染检测并针对HPV的综合治疗能够有效预防和控制宫颈癌及其癌前病变的发生,值得广泛推广运用。

Objective:To investigate the distribution of HPV isoforms in cervical precancerous lesions and cervical cancer.Methods:From January 2015 to January 2017,124 cases of cervical cancer and precancerous lesions were selected in our hospital,among which 36 cases were of cervical cancer and 88 cases of precancerous lesions were of cervical cancer.The cervical exfoliated cells of all patients were collected,and the human papillomavirus was detected to observe and analyze the distribution of different subtypes of HPV in cervical precancerous lesions and cervical carcinoma.Results:A total of 89 cases(71.77%) were detected HPV positive,in which cervical cancer patients with positive detection rate was 100%,significantly higher than that of precancerous lesions in patients with positive rate of 60.23%(P<0.05).The infection rate of HPV18 and HPV16 subtypes was the highest in cervical cancer patients,with 44.44% and 47.22%,respectively.Among the 88 cases of cervical precancerous lesions,the infection rates of HPV33 and HPV52 and HPV16 subtypes in low grade patients were the highest,9.68% and 32.36% and 32.36%,respectively,and the highest rates of HPV58,HPV52 and HPV18 and HPV16 subtypes in advanced type patients were 13.64%,13.64%,22.73%,31.83% respectively.In 89 cases of HPV infection,there were 9 cases of patients with multiple infection and multiple infection rate was 10.11%,and the three and above infection rate was 3.37%.All cervical cancer patients with HPV infection were single infection.The low grade multiple infection rate was 9.68% in patients with precancerous lesions,and the high level multiple infection rate was 27.27%.Conclusion:HPV16 and HPV18 subtype infection rates were higher in patients with cervical cancer and precancerous lesions,and higher infection rates were also found in HPV58 and HPV52 subtypes in patients with precancerous lesions.The clinical use of HPV infection and the comprehensive treatment of HPV can effectively prevent and control the occurrence of cervical cancer and precancerous lesions,and it is worthy to be widely used.