参麦注射液对胸外科手术患者补体水平的干预作用

Intervention of Shenmai Injection on Complement Level in Patients Undergoing Thoracic Surgery

目的:探讨参麦注射液对胸外科手术患者补体水平的干预作用。方法:选取2012年3月至2018年3月四川大学华西医院收治的拟行胸外科手术患者96例,以随机数字表法分为观察组和对照组,每组48例。对照组患者于围术期给予常规治疗,观察组患者在对照组的基础上于麻醉诱导后至术后第5日给予参麦注射液。比较术前,术后1、4及48 h两组患者血清炎性因子[白细胞介素6(IL-6)、白细胞介素8(IL-8)]水平,补体C3、C4水平及免疫功能水平的差异。结果:术后1、4及48 h,两组患者IL-6、IL-8水平明显高于治疗前,而观察组患者IL-6、IL-8水平明显低于对照组,差异均有统计学意义(P<0.05);术后1、4及48 h,两组患者补体C3、C4水平明显低于术前,且观察组患者术后1 h补体C3水平明显高于对照组,差异均有统计学意义(P<0.05);术后1、4及48 h,两组患者CD3^+、CD4^+及CD4^+/CD8^+水平明显低于术前,且观察组患者术后1 h的CD3^+、CD4^+及CD4^+/CD8^+水平明显低于对照组,差异均有统计学意义(P<0.05)。结论:参麦注射液可明显降低胸外科手术患者的炎性因子水平,降低补体C3、C4水平,改善患者免疫功能。

OBJECTIVE:To investigate the intervention of Shenmai injection on the complement level of patients undergoing thoracic surgery.METHODS:Totally 96 patients undergoing thoracic surgery admitted into West China Hospital,Sichuan University from Mar.2012 to Mar.2018 were extracted to be divided into the observation group and the control group via the random number table,with 48 cases in each group.Patients in the control group were given routine treatment during the perioperative period,while the observation group received Shenmai injection from the induction of anesthesia to the 5th day after surgery.Serum levels of inflammatory cytokines (interleukin 6 (IL-6) and interleukin 8 (IL-8)],complement C3,C4 and immune function were compared between two groups before surgery and after surgery of 1,4 and 48 h.RESULTS:After surgery of 1,4 and 48 h,the levels of IL-6 and IL-8 in two groups were significantly higher than those before treatment,while the levels of IL-6 and IL-8 in the observation group were significantly lower than those in the control group ( P <0.05).After surgery of 1,4 and 48 h,the levels of complement C3 and C4 in two groups were significantly decreased compared with before surgery,and the level of complement C3 in the observation group was significantly higher than that in the control group after surgery of 1 h ( P < 0.05).After surgery of 1,4 and 48 h,the levels of CD3^+,CD4^+ and CD4^+/CD8^+ in two groups were significantly decreased compared with before surgery,and the levels of CD3^+,CD4^+ and CD4^+/CD8^+ in the observation group were significantly lower than those in the control group after surgery of 1 h ( P <0.05).CONCLUSIONS:Shenmai injection can significantly reduce the level of inflammatory factors in patients undergoing thoracic surgery,reduce the levels of complement C3 and C4,and improve the immune function of patients.