氧气驱动雾化吸入布地奈德与乙酰半胱氨酸联合治疗小儿毛细支气管炎的疗效观察

Efficacy of Oxygen-Driven Aerosol Inhalation of Budesonide Combined with Acetylcysteine in Treatment of Children with Bronchiolitis

目的:探讨氧气驱动雾化吸入布地奈德与乙酰半胱氨酸联合治疗小儿毛细支气管炎的疗效。方法:选取2017年3月至2018年3月重庆市巴南区人民医院收治的小儿毛细支气管炎患者84例,以随机数字表法分为观察组和对照组,每组42例。两组患儿均给予常规吸氧、保持呼吸道通畅、抗病毒及止咳平喘等对症支持治疗,在此基础上,观察组患儿加用布地奈德与乙酰半胱氨酸,氧气驱动雾化吸入,连续治疗7 d。观察两组患儿症状体征消失时间、住院时间、临床疗效及不良反应发生情况。结果:观察组患儿喘憋消失时间、咳嗽消失时间、肺部啰音消失时间及住院时间明显短于对照组,差异均有统计学意义(P<0.05);观察组患儿的总有效率为95.2%(40/42),明显高于对照组的78.6%(33/42),差异有统计学意义(P<0.05);观察组、对照组患儿的不良反应发生率分别为7.1%(3/42)、11.9%(5/42),差异无统计学意义(P>0.05)。结论:氧气驱动雾化吸入布地奈德与乙酰半胱氨酸联合治疗小儿毛细支气管炎的疗效较好,能够快速缓解患儿症状,缩短病程。

OBJECTIVE:To probe into the efficacy of oxygen-driven aerosol inhalation of budesonide combined with acetylcysteine in treatment of children with bronchiolitis.METHODS:Totally 84 children with bronchiolitis admitted into Banan People’s Hospital of Chongqing from Mar.2017 to Mar.2018 were extracted to be divided into the observation group and the control group via the random number table,with 42 cases in each group.Both groups were given conventional oxygen therapy,airway maintenance,antiviral and antitussive and antiasthmatic and other symptomatic supportive treatment.On this basis,patients in the observation group were treated with oxygen-driven aerosol inhalation of budesonide combined with acetylcysteine,both groups were treated continuously for 7 d.The disappearance time of symptoms and signs,hospitalization time,clinical efficacy and adverse drug reactions were observed in two groups.RESULTS:The disappearance time of wheezing,coughing,rale and hospitalization time in the observation group were significantly shorter than those in the control group ( P <0.05).The total effective rate of the observation group was 95.2%(40/42),significantly higher than that of the control group 78.6%(33/42),with statistically significant difference ( P <0.05).The incidence of adverse drug reactions in the observation group and the control group were 7.1%(3/42) and 11.9%(5/42),respectively,and the difference was not statistically significant ( P >0.05).CONCLUSIONS:The efficacy of oxygen-driven aerosol inhalation of budesonide combined with acetylcysteine in treatment of children with bronchiolitis is significant,which can quickly relieve the symptoms of children and shorten the course of the disease.