丹参川芎嗪注射液对脑梗死患者血液流变学的影响

Effects of Salviae Miltiorrhizae and Ligustrazine Hydrochloride Injection on Hemorheology in Patients with Cerebral Infarction

目的:探讨丹参川芎嗪注射液对脑梗死患者血液流变学的影响。方法:回顾性选取2015年5月至2018年5月连云港市赣榆区人民医院收治的脑梗死患者180例,根据治疗方法的不同分为对照组(93例)和观察组(87例)。对照组患者采用降压、抗感染、纠正水和电解质紊乱、抗血小板聚集、改善循环、营养神经、清除自由基及予以阿司匹林肠溶片等常规治疗,观察组患者在对照组的基础上加用丹参川芎嗪注射液,两组患者均治疗12周。观察两组患者治疗前后血液流变学指标水平、生活质量及不良反应发生情况。结果:治疗后,两组患者血小板聚集率、血浆纤维蛋白原、全血高切黏度、全血低切黏度、红细胞聚集指数及血沉水平明显低于治疗前,且观察组患者明显低于对照组,差异均有统计学意义(P<0.05);两组患者社会功能、物质生活、躯体功能及心理功能评分明显高于同组治疗前,且观察组患者明显高于对照组,差异均有统计学意义(P<0.05)。治疗期间,两组患者出现呕吐、腹泻等,但症状较轻,未影响治疗。结论:在常规治疗的基础上加用丹参川芎嗪注射液可降低脑梗死患者的血液流变学指标水平。

OBJECTIVE:To probe into the effects of salviae miltiorrhizae and ligustrazine hydrochloride injection on hemorheology in patients with cerebral infarction.METHODS:Totally 180 patients with cerebral infarction admitted into Lianyungang Ganyu District People’s Hospital from May 2015 to May.2018 were extracted to be divided into the control group ( n =93) and the observation group ( n =87) via different treatment methods.Patients in the control group were treated with routine treatments such as hypotension,anti-infection,correction of water and electrolyte,anti-platelet aggregation,improvement of circulation,nourishing nerve free radical scavenging drugs and aspirin enteric-coated tablets,while the observation group received salviae miltiorrhizae and ligustrazine hydrochloride injection on the basis of the control group.Both groups were treated for 12 weeks.The hemorheological indexes,quality of life and adverse drug reactions were observed before and after treatment.RESULTS:After treatment,the platelet aggregation rate,plasma fibrinogen,whole blood high-viscosity,whole blood low-cut viscosity,erythrocyte aggregation index and erythrocyte sedimentation rate in two groups were significantly lower than those of the same group before treatment,and the observation group was significantly lower than the control group,with statistically significant differences ( P <0.05).The social function,material life,physical function and psychological function scores of two groups were significantly higher than those of the same group before treatment,and the observation group was significantly higher than the control group,the difference was statistically significant ( P< 0.05).During the treatment,vomiting and diarrhea occurred in both groups,but the symptoms were mild and the treatment was not affected.CONCLUSIONS:On the basis of routine treatment,hemorheological indexes of patients with cerebral infarction can be reduced by using salviae miltiorrhizae and ligustrazine hydrochloride injection.