ALA光动力疗法治疗面部中重度痤疮的疗效和安全性分析

Efficacy and Safety of ALA Photodynamic Therapy for Moderate to Severe Facial Acne

目的探索5-氨基酮戊酸光动力疗法(Aminolevulinic acid photodynamic therapy,ALA-PDT)治疗面部中重度痤疮的疗效和安全性.方法2015年10月至2017年6月,94例中重度痤疮患者随机分为观察组(n=47)和对照组(n=47).观察组采用ALA-PDT治疗,对照组采用红蓝光照射治疗.对比两组患者的疗效、血清TNF-α、IL-8水平变化及不良反应发生情况.结果治疗后2、4、8周,观察组有效率明显高于对照组(P<0.05);观察组的TNF-α及IL-8水平较对照组明显降低(P<0.05);观察组不良反应发生率为12.77%,对照组患者为8.51%,两组无统计学差异(P>0.05).结论ALA-PDT治疗面部中重度痤疮的疗效优于红蓝光照射,且无明显副作用,值得临床推广.

Objective To explore the efficacy and safety of 5-aminolevulinic acid photodynamic therapy for moderate to severe facial acne.Methods A total of 94 cases of moderately severe acne were selected from October 2015 to June 2017,and were divided into control group(n=47)and observation group(n=47).The patients in control group were treated with red and blue light,while the patients in observation group were treated with 5-aminolevulinic acid photodynamic therapy.Clinical curative effect,serum TNF-αand IL-8 levels and adverse reactions of the two groups were compared.Results After treatment for 2,4 and 8 weeks,the effective rates of the observation group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).Serum TNF-αand IL-8 level of observation group after treatment was lower than that of the control group(P<0.05).The incidence of adverse reactions was 12.77%in the observation group and 8.51%in the control group.There was no significant difference between the two groups(P>0.05).Conclusion The efficacy of ALA-PDT in the treatment of moderate to severe acne was significantly better than red and blue light treatment,and the recurrence rate was low,it is worthy of clinical application.