摘要
目的探索5-氨基酮戊酸光动力疗法(Aminolevulinic acid photodynamic therapy,ALA-PDT)治疗面部中重度痤疮的疗效和安全性.方法2015年10月至2017年6月,94例中重度痤疮患者随机分为观察组(n=47)和对照组(n=47).观察组采用ALA-PDT治疗,对照组采用红蓝光照射治疗.对比两组患者的疗效、血清TNF-α、IL-8水平变化及不良反应发生情况.结果治疗后2、4、8周,观察组有效率明显高于对照组(P<0.05);观察组的TNF-α及IL-8水平较对照组明显降低(P<0.05);观察组不良反应发生率为12.77%,对照组患者为8.51%,两组无统计学差异(P>0.05).结论ALA-PDT治疗面部中重度痤疮的疗效优于红蓝光照射,且无明显副作用,值得临床推广.
Objective To explore the efficacy and safety of 5-aminolevulinic acid photodynamic therapy for moderate to severe facial acne.Methods A total of 94 cases of moderately severe acne were selected from October 2015 to June 2017,and were divided into control group(n=47)and observation group(n=47).The patients in control group were treated with red and blue light,while the patients in observation group were treated with 5-aminolevulinic acid photodynamic therapy.Clinical curative effect,serum TNF-αand IL-8 levels and adverse reactions of the two groups were compared.Results After treatment for 2,4 and 8 weeks,the effective rates of the observation group were significantly higher than those of the control group,and the difference was statistically significant(P<0.05).Serum TNF-αand IL-8 level of observation group after treatment was lower than that of the control group(P<0.05).The incidence of adverse reactions was 12.77%in the observation group and 8.51%in the control group.There was no significant difference between the two groups(P>0.05).Conclusion The efficacy of ALA-PDT in the treatment of moderate to severe acne was significantly better than red and blue light treatment,and the recurrence rate was low,it is worthy of clinical application.
作者
李晓庆
徐素平
孔迎辉
李鹤
徐漫远
江明
孙卫国
LI Xiaoqing;XU Suping;KONG Yinghui;LI He;XU Manyuan;JIANG Ming;SUN Weiguo(Department of Dermatology,Huaian First Hospital Affiliated to Nanjing Medical University,Huaian 223300,China.)
出处
《组织工程与重建外科杂志》
2019年第3期191-193,共3页
Journal of Tissue Engineering and Reconstructive Surgery