中性粒细胞及血小板与淋巴细胞比值与2型糖尿病视网膜病变相关性

Correlation of neutrophil-to-lymphocyte ratio,platelet-to-lymphocyte ratio and type 2 diabetic retinopathy

目的:探讨中性粒细胞与淋巴细胞比值(NLR)、血小板与淋巴细胞比值(PLR)与2型糖尿病视网膜病变(DR)的相关性。方法:选择2型糖尿病(DM)患者200例,按眼底检查结果分为眼底正常组( n =100)、非增殖期视网膜病变组(NPDR, n =62)和增殖期视网膜病变组(PDR, n =38)。同时选取100例健康体检者作为正常对照( n =100)组;测定中性粒细胞、淋巴细胞及血小板计数等相关指标。结果: PDR组患者NLR值(2.54)高于对照组(1.81)、DM组(1.76)及NPDR组(1.85),差异有统计学意义( P <0.05),PDR组患者PLR值(126.18)高于DM组(111.64),差异有统计学意义( P <0.05)。Logistic回归分析显示,年龄(β=-0.047)是糖尿病视网膜病变的保护因素( P <0.05),病程(β=0.071)和收缩压(β=0.024)是危险因素( P <0.05),而NLR、PLR在回归分析中无统计学意义。结论:NLR、PLR值在PDR组升高,但并非糖尿病视网膜病变发生的独立危险因素。

AIM: To investigate the relationship between neutrophil- to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and type 2 diabetic retinopathy (DR). METHODS:A total of 200 cases with type 2 diabetes mellitus were involved. All patients were divided into three groups according to the fundus examination: diabetes mellitus (DM, n =100), non-proliferative diabetic retinopathy (NPDR, n =62) and proliferative diabetic retinopathy (PDR, n =38). 100 healthy persons were selected as the normal control group (NCG, n =100). The related indicators, such as neutrophil count, lymphocyte count and platelet count were measured. RESULTS: The value of NLR was significantly higher in PDR group patients than in NC group (1.81), DM group (1.76) and NPDR group (1.85)( P <0.05). The value of PLR was significantly higher in PDR group patients (126.18) than in DM group (111.64)( P <0.05). Logistic regression analysis showed that age (β=-0.047) was protective factor, course of diabetes (β=0.071) and systolic blood pressure (β=0.024) were risk factors for diabetic retinopathy ( P <0.05), but the value of NLR and PLR was not statistically significant in the Logistic regression analysis. CONCLUSION: The value of NLR and PLR increased in the PDR group, but it is not independent risk factor for diabetic retinopathy.