木薯淀粉水凝胶负载姜黄素及缓释性能研究

Curcumin loaded tapioca starch hydrogel and its sustained release

为提高木薯淀粉应用价值,以木薯淀粉为原料,丙烯酰胺为单体,过硫酸钾为引发剂,N,N-亚甲基双丙烯酰胺为交联剂制备具有良好机械性能、可用作药物载体的木薯淀粉水凝胶。通过傅里叶红外光谱、核磁共振、X-射线衍射等分析测试手段对其进行表征。成功制备木薯淀粉水凝胶,且机械性能良好。以制得的水凝胶为载体,探究了水凝胶负载姜黄素的载药性能及缓释性能。结果表明:载药性能良好,最佳载药条件为载药时间0.5h,乙醇体积分数20%,温度35℃,药液初始浓度100μg/mL,载药量可达到100mg/g。纯姜黄素与负载于水凝胶中的姜黄素作对照,纯姜黄素突释明显,水凝胶中姜黄素释放缓慢,72h后累积释药率达到80%左右,表明水凝胶作为载体具有药物缓释的作用。

In order to improve the application value of tapioca starch,a tapioca starch hydrogel was prepared by using cassava starch as raw material,acrylamide as a monomer,potassium persulfate as an initiator,and N,N -methylenebisacrylamide as a cross-linking agent. It was characterized by fourier transform infrared spectroscopy,nuclear magnetic resonance,X-ray diffraction and other analytical methods. The results showed that the tapioca starch hydrogel had been successfully prepared and had good mechanical properties. Moreover,by using curcumin as a drug,it was found that the drug-loading performance of the hydrogel was good,and the optimal drug loading condition was as follows: at 35 ℃,loaded 100 μg/mL initial drug solution for 0.5 h with 20% ethanol. Under this condition,the drug loading amount could reach to 100 mg/g. By comparing pure curcumin and curcumin loaded in the hydrogel,the pure curcumin showed significant sudden release,while the curcumin in the hydrogel was released slowly,and the cumulative release rate reached about 80% after 72 h,indicating that the hydrogel could achieve sustained release of drugs.