哈尔滨居民膳食镁摄入量及膳食模式与2型糖尿病患病风险的关联研究

Association between dietary magnesium and the risk of type 2 diabetes in Harbin residents

目的探讨膳食镁摄入量及膳食模式与2型糖尿病的关联。方法于2010年4月采取多阶段随机整群抽样方法,以哈尔滨7个区的24个社区为研究现场,对9 734名调查对象20~74岁居民进行问卷调查、膳食调查以及血糖检测,最终9 376名调查对象纳入分析。采用因子分析法分析膳食模式。根据膳食镁摄入量的四分位数将调查对象分为Q1~Q4组,采用多因素logistic回归模型,分析膳食镁的摄入量及不同膳食模式下膳食镁与2型糖尿病患病风险的关系。结果9 376名调查对象中,筛查出2型糖尿病患者998例。糖尿病组和非糖尿病组年龄M分别为54.8、50.8岁,男性分别占43.4%(2 896名)、34.6%(433例),镁摄入量M(P25,P75)分别为336.36(257.31,440.65)、339.50(264.51,443.78)mg/d。通过因子分析得到4种膳食模式,分别为西方、精明、传统、主食型膳食模式。西方膳食模式中,与膳食镁摄入Q1组相比,Q4组糖尿病患病风险较高,OR(95%CI)值为1.56(1.06~2.32);然而在精明膳食模式下,与膳食镁摄入Q1组相比,Q4组糖尿病患病风险较低,OR(95%CI)值为0.61(0.37~0.96)。在不考虑膳食模式情况下,膳食镁摄入量与2型糖尿病患病风险关联无统计学意义(P>0.05)。结论在不同的膳食模式下,膳食镁摄入量与2型糖尿病患病风险的关系不同。

Objective To investigate the relationship between the magnesium intake and patterns of diary and the risk of type 2 diabetes in Harbin residents.Methods On April 2010,24 communities in 7 districts of Harbin were selected as research sites using multi-stage stratified random cluster sampling method.A total of 9 734 residents aged 20-74 years was investigated using general questionnaire survey,dietary survey and biochemical indicators test.A total of 9 376 subjects were included in the study.Factor analysis was used to analyze dietary patterns.According to the quartile of dietary magnesium intake,the subjects were divided into four groups,from Q1 to Q4 group.The multivariate logistic regression model was used to analyze the relationship between dietary magnesium intake and the risk of type 2 diabetes within different dietary patterns.Results A total of 998 subjects with type 2 diabetes were screened.The median age of the diabetic group and the non-diabetic group were 54.8 and 50.8,respectively,and the males accounted for 43.4%(2 896 cases)and 34.6%(433 cases),respectively.The magnesium intake median(P25,P75)of two groups was 336.36(257.31,440.65)and 339.50(264.51,443.78)mg/d.Four dietary patterns were identified as western dietary mode,savvy dietary mode,traditional dietary mode,and staple food mode.In the western dietary model,the Q4 group had a higher risk of type 2 diabetes than Q1 group,with an OR(95%CI)value of 1.56(1.06 to 2.32).However,in the savvy diet mode,compared with the Q1 group,the risk of diabetes in the Q4 group was lower,and the OR(95%CI)value was 0.61(0.37 to 0.96).There was no statistically significant association between dietary magnesium intake and the risk of type 2 diabetes without considering dietary patterns(P>0.05).Conclusion Dietary magnesium intake has a different relationship with the risk of type 2 diabetes within different dietary patterns.