妊娠期维生素D水平与脂代谢

The association of Vitamin D levels with lipid metabolism during pregnancy

维生素D缺乏在孕妇人群均十分普遍,它与多种妊娠期并发症、胎儿宫内发育异常以及产后远期的母婴健康均存在关联。维生素D参与脂代谢,并可能通过此生物学途径影响妊娠期母胎健康。本文主要从维生素D影响脂代谢的作用机制、妊娠期维生素D与脂代谢物关联以及妊娠并发症孕妇的维生素D与脂代谢关系三个方面进行了综述。目前的多数研究支持孕期不同阶段的维生素D状态与脂代谢之间均存在关联,潜在机制已经被部分阐明。由于一些妊娠并发症如妊娠期糖尿病和先兆子痫孕妇往往容易伴随脂代谢异常和维生素D缺乏,对孕妇进行维生素D补充与脂代谢改善的研究具有重要临床价值。今后需要开展多中心、大样本、多剂量干预的随机对照试验研究,为临床实践提供科学依据。

Vitamin D deficiency is common in pregnant women,and it is associated with multiple gestational complications,fetal intrauterine dysplasia,and maternal and infant health in postpartum period.Vitamin D involved in lipid metabolism may affect maternal-fetal health during pregnancy through this biological pathway.This review provides an overview of three main aspects,including,the effect of vitamin D on the mechanism of lipid metabolism,the relationship between vitamin D and lipid metabolites in pregnant women and women with pregnancy complications.An association between vitamin D status and lipid metabolism at different stages of pregnancy has been justified in most current studies,and the underlying mechanism has also been partly elucidated.Given some gestational complications,such as gestational diabetes and pre-eclampsia,pregnant women with these conditions are often associated with abnormal lipid metabolism and vitamin D deficiency.There is no doubt that the studies on the vitamin D supplementation and lipid metabolism improvement could have crucial clinical significance for this population.More randomized controlled trials with multi-center,large sample and multi-dose interventions are needed in the future to provide scientific evidence for clinical practice.