固有淋巴细胞研究进展

Research progress in innate lymphoid cells

固有淋巴细胞(innate lymphoid cells,ILCs)是一群新近发现的具有适应性免疫功能的固有免疫细胞,分化源于共同淋巴祖细胞(common lymphoid progenitor,CLP),存在于全身多个组织中。根据其分泌的细胞因子和表达的转录因子可以分为3个亚群:ILC1s、ILC2s和ILC3s,这些异质性免疫细胞群在机体不同组织中发挥着不同的作用,参与组织重塑、修复愈合,抗寄生虫、致病菌感染,并与肿瘤的发生、机体代谢的稳定以及共生菌免疫耐受的形成等有关。本文就ILC的分类、分化发育来源及最新功能研究进展做一综述。

The newly identified innate lymphoid cells(ILCs)are a member of innate lymphocytes which functionally resemble adaptive lymphocytes.ILCs arise from a common lymphoid progenitor(CLP)and locate in multiple tissues.Three distinct groups of ILCs have been identified on the basis of transcription factors and expression of effector cytokines and termed ILC1s,ILC2s and ILC3s.These heterogeneous subsets play different roles in different tissues.They are involved in tissue remodeling,healing,anti-parasitic and anti-bacterial infections,tumor development,metabolic stability and immune tolerance to symbiotic microorganisms.Here we focused on the most recent data concerning the classification,development and differentiation of ILCs as well as the new functions of ILCs.