脓毒症致获得性肌无力相关机制的研究进展

Mechanism of sepsis-induced acquired weakness

脓毒症可导致神经、肌膜、神经肌肉接头(neuromuscular junction, NMJ)以及兴奋收缩耦联改变,促进肌无力发生、发展。获得性肌无力延长患者机械通气和住院时间,是导致脓毒症患者病死率增高的独立危险因素,严重影响患者的生活质量。文章围绕近年来有关脓毒症致获得性肌无力的相关机制研究进展进行综述,为临床工作提供理论依据。虽然目前脓毒症致获得性肌无力机制尚不完全清楚,但随着研究不断深入,有望为临床诊疗及麻醉奠定坚实的理论基础。

Sepsis can cause changes of nerve, sarcolemma, neuromuscular junction (NMJ) and excitation-contraction coupling for promoting the acquired muscle weakness. Acquired weakness of muscles can prolong the time of mechanical ventilation and hospital stay of patients. It is an independent risk factor leading to the increase of mortality in critically ill patients and seriously affects the patients′ quality of life. In this paper, the research progress of the mechanism of sepsis-induced acquired weakness in recent years is reviewed so as to provide theoretical basis for clinical work. Although the mechanism of sepsis-induced acquired weakness is not fully understood at present,further research will lay a solid theoretical foundation for clinical diagnosis, treatment and anesthesia.