脓毒症中性粒细胞功能障碍的研究进展

Research progress on neutrophil dysfunction during sepsis

脓毒症是宿主对感染反应失调所引起的严重器官功能障碍,中性粒细胞是免疫应答的重要细胞,在脓毒症中起重要作用.文章对脓毒症时中性粒细胞功能障碍及机制进行概述(一方面脓毒症时中性粒细胞向感染部位迁移能力受损,不能有效清除感染;另一方面,中性粒细胞大量聚集可能导致组织损伤和器官功能障碍),分析总结中性粒细胞在脓毒症中的作用.中性粒细胞在脓毒症的发生、发展中起着重要作用,其具体机制还需要更深入的研究和探索,以充分发挥其应有的医学价值.

Sepsis is a syndrome of life-threatening organ dysfunction caused by a dysregulated host response to infection. Neutrophils are essential players in the host defense against invading pathogens. This review provides an overview of neutrophils dysfunction and the underlying mechanism in the sepsis. Several investigations have shown that impairment of neutrophil migration to the site of infection occurs during sepsis, resulting in an inability of the host to eliminate the infection. On the other hand, the neutrophil accumulation contributes to tissue damage and organ dysfunction during sepsis. This review summarizes the role and the potential mechanism of neutrophils in the sepsis. Neutrophils play an important role in the development of sepsis. Thus, its specific mechanisms need to be further studied and explored to give full play to its proper medical value.