摘要
牛病毒性腹泻病毒(BVDV)是引起牛病毒性腹泻-黏膜病(BVD-MD)的病原,感染后可造成牛腹泻、流产、繁殖障碍、持续感染等症状,且急性BVD致死率较高,对我国乃至世界养牛业造成了严重影响。目前,国内外对BVDV的研究主要聚焦在其结构蛋白方面,对于在BVDV复制、转录、翻译中起重要作用的非结构蛋白的研究较少,缺乏对BVDV非结构蛋白的功能进行系统的总结。论文对BVDV非结构蛋白功能方面近年来的研究进展进行了汇总,以期对今后牛病毒性腹泻黏膜病的致病机制、诊断及预防提供参考。
Bovine viral diarrhea virus (BVDV) is the causative agent of bovine viral diarrhea-mucosal disease(BVD-MD),which can cause the symptoms of diarrhoea,abortion,reproductive failure and persistent infection.The acute BVD-MD has a high mortality,and BVD-MD has atremendous impact on our even world's cattle industry.Then,the non-structural proteins of BVDV plays an important role in the replication,transcription and translation of BVDV.However,there are few systematic reviews on the functional aspects of BVDV nonstructural proteins.Therefore,the author summarized the advances of the studies on non-structual proteins' functions of BVDV,to give some reference value for BVDV diagnosis and prevention in the future.
作者
姚泽慧
刁乃超
李大帅
田甜
董守艺
童婷蓉
蔺晓谕
王慧慧
时坤
杜锐
YAO Ze-hui;DIAO Nai-chao;LI Da-shuai;TIAN Tian;DONG Shou-yi;TONG Ting-rong;LIN Xiao-yi;WANG Hui-hui;SHI Kun;DU Rui(College of Animal Science &Technology,Jilin Agricultural University,Changchun,Jilin,130118,China;College of Chinese Medicine Materials,Jilin Agricultural University,Changchun,Jilin,130118,China;Laboratory of Production and Product Application of Sika Deer of Jilin Province,Changchun,Jilin,130118,China)
出处
《动物医学进展》
北大核心
2019年第7期87-91,共5页
Progress In Veterinary Medicine
基金
国家自然科学基金项目(31672577)
国家重点研发计划专项项目(2018YFD0500900)
吉林省教育厅科学技术研究项目(JJKH20180697KJ)
吉林农业大学本科生科技创新基金项目(2017)
关键词
牛病毒性腹泻病毒
非结构蛋白
致病机制
Bovine viral diarrhea virus
non-structual protein
pathogenic mechanism
