MicroRNA-155在结核分支杆菌与巨噬细胞互作中调控作用的研究进展

Progress on microRNA-155 in Interaction between Mycobacterium tuberculosis and Macrophages

microRNAs是广泛存在于真核生物中的小分子非编码RNA,在转录后水平调节多种生物进程,包括细胞分化和发育、免疫反应、凋亡等。microRNA-155是一个多功能的microRNA,研究发现microRNA-155在结核分支杆菌与巨噬细胞互作中发挥着重要的调控作用,巨噬细胞是结核分支杆菌在体内的主要宿主细胞,结核分支杆菌与巨噬细胞互作的结果与结核病的发展密切相关。论文对结核分支杆菌与巨噬细胞互作中microRNA-155调控细胞自噬、细胞凋亡、细胞杀菌能力等作用的研究进展进行综述,以期为结核病的诊断和治疗提供新的思路。

MicroRNAs are a kind of short non-coding RNAs which widely present in eukaryotes,and can regulate a variety of biological processes at post-transcriptional levels,including cell differentiation and development,immune response,and apoptosis.MicroRNA-155 is a multifunctional microRNA and plays an important role in regulating the interaction between Mycobacterium tuberculosis and macrophages.Macrophage is the main host cell of Mycobacterium tuberculosis,the interaction between Mycobacterium tuberculosis and macrophages is closely related to the development of tuberculosis.Therefore,this review summarized the advances in the roles of microRNA-155 regulated cellular autophagy,apoptosis and bactericidal activity in the interaction between Mycobacterium tuberculosis and macrophages,hoping to provide new thought for the therapy and diagnosis of tuberculosis.