血清转铁蛋白、C反应蛋白和红细胞免疫功能检测对新生儿黄疸的诊断价值

Value of detection in serum transferrin,C reactive protein and erythrocyte immune function in diagnosis of neonatal jaundice

目的探讨血清转铁蛋白(TRF)、C反应蛋白(CRP)和红细胞免疫功能水平检测在新生儿黄疸诊断中的价值。方法收集本院2016年3月—2018年3月新生儿科确诊的100例黄疸新生儿和80例足月健康新生儿,分别记为黄疸组和健康组。根据黄疸类型和总胆红素(TBIL)水平,将黄疸组分为生理性黄疸组(n=43)和病理性黄疸组(n=57);根据黄疸病情程度将黄疸组患儿分为轻中度黄疸组(n=69)和重度黄疸组(n=31)。检测新生儿的血清TRF、CRP、红细胞免疫复合物花环(RBC-ICR)、红细胞C3b受体花环(RBCC3bR)、红细胞免疫亲和力受体(FEER)水平;比较黄疸组和健康组、黄疸各亚组上述指标水平差异。结果与健康组比较,黄疸组血清TRF、RBC-C3bR、FEER水平显著偏低,CRP、RBC-ICR水平显著较高,差异有统计学意义(P<0.05);生理性黄疸组血清TRF、RBC-C3bR、FEER水平高于病理性黄疸组,CRP、RBCICR水平显著低于病理性黄疸组(P<0.05);轻中度黄疸组血清TRF、RBC-C3bR、FEER水平显著高于重度黄疸组,CRP、RBC-ICR水平低于重度黄疸组,差异有统计学意义(P<0.05)。结论黄疸新生儿血清TRF、CRP的表达和红细胞免疫功能呈异常状态,且不同类型和不同病情程度黄疸新生儿上述指标也存在显著差异,对临床诊断新生儿黄疸具有一定参考价值。

Objective To explore the diagnostic value of serum transferrin (TRF), C reactive protein (CRP) and erythrocyte immune function detection in neonatal jaundice. Methods A total of 100 jaundiced newborns from March 2016 to March 2018 and 80 full-term healthy newborns were collected in our hospital, and were divided into jaundice group and healthy group. Jaundice patients were further divided into physiological jaundice group ( n =43), and pathological jaundice group ( n =57) according to the type of jaundice and the level of total bilirubin (TBIL), mild to moderate jaundice group ( n =69) and severe jaundice group ( n =31) according to the severity degree of jaundice. The levels of TRF, CRP, erythrocyte immune complex resette(RBC-ICR), erythrocyte C3b receptor rosette(RBC-C3bR) and erythrocyte immune affinity receptor(FEER) in serum of the newborns were detected. The differences of the above indexes between jaundice group and its subgroups, healthy group were compared. Results Compared with the healthy group, the levels of TRF, RBC-C3bR, FEER in jaundice group were significantly lower, while levels of CRP and RBC-ICR were significantly higher ( P <0.05). The levels of TRF, RBC-C3bR and FEER in serum of physiological jaundice group were higher than that in pathological jaundice group, while the levels of CRP and RBC-ICR were significantly lower than that in pathological jaundice group( P <0.05). The levels of TRF, RBC-C3bR and FEER in mild and moderate jaundice group were significantly higher than that in severe jaundice group, while the levels of CRP, RBC-ICR in mild and moderate jaundice group were significantly lower than those in severe jaundice group ( P <0.05). Conclusion The levels of serum TRF, CRP and erythrocyte immune function of jaundiced neonates show abnormal status, and there are significant differences between different types and different severity degrees of jaundiced neonates, which is of great value for clinical diagnosis of neonatal jaundice.