通心络、甘露消渴胶囊联合西医常规治疗对冠心病合并糖尿病的疗效

Effect of Tongxinluo Capsule and Ganlu Xiaoke Capsule combined with routine treatment of western medicine for coronary heart disease complicated with diabetes

目的探讨通心络胶囊及甘露消渴胶囊联合西医常规治疗对冠心病合并糖尿病的疗效。方法选择冠心病合并糖尿病患者200例为研究对象,按照随机数表法随机分为对照组和干预组,每组100例。对照组采用抗冠心病与常规降血糖等西药治疗,干预组在对照组基础上采用通心络胶囊及甘露消渴胶囊进行治疗,比较2组患者心绞痛持续时间、发作次数、硝酸甘油服用量、血液流变学指标、心电图疗效及血糖控制状况。结果治疗前,2组患者心绞痛持续时间、发作次数、硝酸甘油服用量无显著差异(P>0.05);治疗后,干预组患者心绞痛持续时间、发作次数、硝酸甘油服用量均显著低于对照组(P<0.05)。治疗前,2组患者全血黏度、红细胞压积、血浆比黏度无显著差异(P>0.05);治疗后,干预组患者全血黏度、红细胞压积、血浆比黏度均显著低于对照组(P<0.05)。干预组心电图疗效有效率(88.00%)显著高于对照组(63.00%)(P<0.05);干预组血糖控制总有效率(96.00%)显著高于对照组(79.00%)(P<0.05)。结论通心络胶囊及甘露消渴胶囊联合西医常规治疗应用于冠心病合并糖尿病患者,能明显改善糖脂代谢异常导致的心血管损害,且能明显降低血流动力学指标水平,改善微循环,使心绞痛持续时间、次数及用药量得以降低。

Objective To study the efficacy of Tongxinluo Capsule and Ganlu Xiaoke Capsule combined with routine treatment of western medicine in the treatment of coronary heart disease with diabetes mellitus. Methods A total of 200 patients with coronary heart disease and diabetes mellitus treated in our hospital were selected as study subjects. According to the random number table method, the patients were randomly divided into control group and intervention group, with 100 cases in each group. Patients in the control group were treated with western medicine such as anti-coronary heart disease drugs and routine hypoglycemia treatment, while those in the intervention group were treated with Tongxinluo Capsule and Ganlu Xiaoke Capsule on the basis of the control group. The duration of angina, the times of attack, the dosage of nitroglycerin, hemorheological parameters, the efficacy of electrocardiogram and blood sugar control were compared and analyzed between the two groups. Results Before treatment, there were no significant differences in duration of angina, attack times and nitroglycerin dosage between the two groups ( P >0.05). After treatment, the above indicators in the intervention group were significantly lower than that in the control group ( P <0.05). After treatment, the whole blood viscosity, hematocrit and blood viscosity of the intervention group were significantly lower than those of the control group ( P <0.05), and the effective rate of ECG in the intervention group was significantly higher than that of the control group (88.00% vs. 63.00%,P <0.05). The total effective rate of blood sugar control in intervention group was significantly higher than that in intervention group (96.00% vs. 79.00%, P <0.05). Conclusion Tongxinluo Capsule and Ganlu Xiaoke Capsule combined with western medicine can significantly improve cardiovascular damage caused by abnormal glucose and lipid metabolism, and significantly reduce hemodynamic parameters, improve microcirculation, and reduce angina duration, attack times and the amount of medication forpatients with coronary heart disease and diabetes.