沈阳市2009—2014年多发性骨髓瘤发病分析

Incidence of Multiple Myeloma in Shenyang from 2009 to 2014

目的分析沈阳市2009-2014年多发性骨髓瘤发病情况及其特征,为沈阳市多发性骨髓瘤的防治提供科学依据。方法收集、整理沈阳市肿瘤登记处的多发性骨髓瘤病例资料,计算发病率、标准化发病率、构成比等指标。结果2009-2014年沈阳市多发性骨髓瘤发病率为1.70/10万,标化率为0.72/10万,在血液系统恶性肿瘤中排在第3位;其中男性发病率为1.88/10万,标化率为0.76/10万,女性发病率为1.53/10万,标化率为0.69/10万,男性发病率高于女性。中位发病年龄为62岁,发病多集中在50~79岁,占全部发病人数的84.57%。6年间2014年发病率是2009年的1.14倍,发病率呈现上升趋势(P<0.01)。从45岁开始发病率迅速升高,70~岁组发病率最高为7.22/10万。结论沈阳市多发性骨髓瘤发病以中老年人群为主,虽然发病率不高,但呈现上升趋势。

Objective To analyze the incidence and characteristics of multiple myeloma in Shenyang from2009 to 2014, and provide scientific evidence for the prevention and treatment of multiple myeloma. Methods The data of multiple myeloma cases in Shenyang Cancer Registry were collected and sorted, and the incidence rate, standardized incidence rate and composition ratio were calculated. Results The incidence of multiple myeloma in Shenyang from 2009 to 2014 was 1.70/100,000, the standardization rate was 0.72/100,000,ranking third in malignant tumors in the blood system;the incidence rate in the male was 1.88/100,000,and the standardization rate was 0.76/100,000;the incidence rate in the female was 1.53/100,000, and the standardization rate was 0.69/100,000. The incidence rate in the male was higher than that in the female. The median age of onset was 62 years old, and the tumor was mostly occurred in 50-79 years old, accounting for84.57% of the total number of cases. In the past 6 years, the incidence rate in 2014 was 1.14 times that of2009, and the incidence rate showed an upward trend(P<0.01). The incidence rate increased rapidly from the age of 45, the highest incidence(7.22/100,000) was found in the ≥70-year-old group. Conclusion The incidence of multiple myeloma in Shenyang is mainly in the middle-aged and elderly population. Although the incidence rate is not high, it shows an upward trend.