期刊文献+

螺旋CT多期扫描与血清CXCL13、NGAL联合检测在肝癌疾病中的诊断意义 被引量:7

下载PDF
导出
摘要 目的 分析螺旋CT多期扫描与血清CXCL13、NGAL联合检测在肝癌疾病中的诊断意义。方法 选择2014年5月至2018年1月在两院进行治疗的疑似肝癌疾病患者67例作为研究对象,入组患者均进行螺旋CT多期扫描,采用ELISA法测定患者血清CXCL13、NGAL水平。结果 肝癌组血清NGAL、CXCL13水平显著高于非肝癌组,统计学分析结果表明差异具有统计学意义(P<0.05)。螺旋CT对肝癌疾病诊断的灵敏度、准确性、特异性、阳性预测值和阴性预测值分别为0.89、0.87、0.62、0.95和0.47,从中可以看出该方法的特异性和阴性预测值均偏低。血清标志物对肝癌疾病诊断的灵敏度、准确性、特异性、阳性预测值和阴性预测值分别为0.88、0.87、0.78、0.96和0.51。螺旋CT联合血清标志物肝癌疾病诊断的灵敏度、准确性、特异性、阳性预测值和阴性预测值分别为0.97、0.95、0.88、0.98和0.80。结论 螺旋CT多期扫描与血清CXCL13、NGAL联合检测在肝癌疾病诊断的灵敏度、准确性及特异性均较高,同时具有较高的阴性预测值和阳性预测值,具有较好的临床应用价值。
出处 《肝脏》 2019年第6期702-704,共3页 Chinese Hepatology
  • 相关文献

参考文献4

二级参考文献59

  • 1Li Zhao, Dong-Cheng Mou, Zeng-An Wu, Ji-Run Peng, Lei Huang, Xi-Sheng Leng.Diagnostic value of cancer-testis antigen mRNA in peripheral blood from hepatocellular carcinoma patients[J].World Journal of Gastroenterology,2010,16(32):4072-4078. 被引量:22
  • 2代岩,王起龙,王静,王焕勤,康燕,袁彦丽.中性粒细胞明胶酶相关蛋白及基质金属蛋白酶10在非小细胞肺癌中的表达及临床意义[J].中国实用医刊,2010,37(5):5-7. 被引量:2
  • 3Lin Zhou,Jia Liu,Feng Luo.Serum tumor markers for detection of hepatocellular carcinoma[J].World Journal of Gastroenterology,2006,12(8):1175-1181. 被引量:78
  • 4Cowland J B,Borregaard N.Molecular characterization and pattern of tissue expression of the gene forneutrophil gelatinase-associated lipocalin from humans[J].Genomics,1997,45(1):17-23.
  • 5Fernández C A,Yan L,Louis G,et al.The matrix metalloproteinase-9/neutrophil gelatinase-associatedlipocalin complex plays a role in breast tumor growth and is present in the urine of breast cancer patients[J].Clin Cancer Res,2005,11(15):5390.
  • 6Kubben F J G M,Sier C F M,Hawinkels L J A C,et al.Clinical evidence for a protective role oflipocalin-2against MMP-9autodegradation and the impact for gastric cancer[J].Eur J Cancer,2007,43(12):1869-1876.
  • 7Chakraborty S.Ngal/Lipocalin-2is a marker of early dysplastic changes in the pancreas and a possiblediagnostic marker in pancreatitis and/or pancreatic adenocarcinoma[J].Cancer Biomarkers,2008,4(3):132-132.
  • 8Yan L,Borregaard N,Kjeldsen L,et al.The high molecular weight urinary matrix metalloproteinase(MMP)activity is a complex of gelatinase B/MMP-9 and neutrophil gelatinase-associated lipocalin(NGAL).Modulation of MMP-9activity by NGAL[J].J Biol Chem,2001,276(40):37258-37265.
  • 9MartíJ,Fuster J,Hotter G,et al.Serum neutrophil gelatinase-associated lipocalin in patients withcolorectal liver metastases:preliminary results of an exploratory prospective study[J].Int J BiolMarkers,2010,25(1):21-26.
  • 10Borkham-Kamphorst E,Drews F,Weiskirchen R,et al.Induction of lipocalin-2expression in acute andchronic experimental liver injury moderated by pro-inflammatory cytokines interleukin-1βthrough nuclearfactor-κB activation[J].Liver Int,2011,31(5):656-665.

共引文献17

同被引文献79

引证文献7

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部