早期宫颈癌术后辅助旋转调强放疗的疗效分析

Effect of Rotational Intensity Modulated Radiotherapy on Early Postoperative Cervical Cancer

目的 探讨早期宫颈癌手术治疗后旋转调强放疗辅助治疗的疗效。方法 选取84例早期宫颈癌病患,根据术后给予的不同辅助治疗方式分为2组,观察组患者给予旋转调强放疗(n=42),对照组患者给予三维适形放疗(n=42)。观察2组疗效并对比分析2组病患生活质量。结果 观察组1年生存率100.00%、2年生存率100.00%、3年生存率97.62%,与对照组95.24%、85.71%、76.19%相比,差异有统计学意义(χ^2=2.05、5.32、7.26,P<0.05)。观察组治疗后病患的躯体功能、认知功能、社会功能等生活质量评分和性生活质量评分与对照组相比,差异有统计学意义(t=7.62、7.54、7.58、9.23,P<0.05)。观察组的白细胞下降、膀胱反应、放射性膀胱、放射性肠炎及消化道反应等不良反应发生率为4.76%(2/42),与对照组23.81%(10/42)相比,差异有统计学意义(χ^2=6.40,P<0.05)。结论 早期宫颈癌手术治疗后给予旋转调强放疗可以有效提高病患的生存率,改善生活质量和性生活质量,降低不良反应的发生率,临床应用价值较高。

Objective To investigate the efficacy of rotational intensity-modulated radiotherapy adjuvant therapy after surgical treatment of early stage cervical cancer. Methods 84 patients with early stage cervical cancer diagnosed and treated in our hospital from April 2013 to April 2015 were divided into 2 groups according to the different adjuvant treatment after surgery.Patients in the observation group ( n =42) were given rotational adjustment.Strong radiation therapy,the control group ( n =42) were given three-dimensional conformal radiotherapy to observe the efficacy of the 2 groups and comparative analysis of the patient's sexual life quality. Results A comparative analysis of the postoperative survival of the patients found that the 1-year survival rate in the observation group was 100%,the 2-year survival rate was 100%,and the 3-year survival rate was 97.62% compared with 95.24%,85.71%,and 76.19% in the control group.The difference was significant (χ^2=2.05,5.32,7.26, P < 0.05 );the quality of life and the quality of life scores of the patients' physical function,cognitive function,social function,etc.after different adjuvant treatments were compared between the observation group and the control group.Significant difference ( t = 7.62 ,7.54,7.58,9.23, P <0.05);the incidence of adverse reactions such as leukopenia,bladder reaction,radioactive bladder,radiation enteritis,and digestive tract reaction,etc.,were compared between different adjuvant treatments.Observation group was 4.76%(2/42) There was a significant difference compared to the control group of 23.81%(10/42)(χ^2=6.40, P <0.05). Conclusion The rotational intensity-modulated radiotherapy given after surgical treatment of early stage cervical cancer can effectively improve the survival rate of patients,improve the quality of life and quality of life,reduce the incidence of adverse reactions,and have high clinical application value.