纳米脂肪的研究进展及临床应用

Research progress and clinical application of nano-fat

背景:近年来人们对纳米脂肪的研究也逐渐拓宽及拓深,其应用也越来越广。目的:综述近年来纳米脂肪的研究及应用。方法:以"Nanofat、Adipose-Derived Stem Cells、fat grafting"为英文检索词,以"纳米脂肪、脂肪干细胞、脂肪移植"为中文检索词,检索中国知网全文数据库、万方全文数据库、维普期刊全文数据库、Pub Med数据库有关纳米脂肪及脂肪干细胞的文献,保留52篇文献进一步总结分析。结果与结论:综合目前对纳米脂肪的研究,证实纳米脂肪在抗衰老、瘢痕、创面修复、填充等效果明显,但样本数据不大,需要更大、更多的样本及数据支撑。目前制备方法得到的纳米脂肪包括多种成分,具体作用机制还需更深层次的研究,且目前制备方法尚无统一标准,诸多环节如:选取脂肪来源、抽吸脂肪方法、机械乳化过滤脂肪程序及纳米脂肪移植注射后的护理等均有待进一步完善。

BACKGROUND: In recent years, there is an increasing area of nano-fat and its clinical application.OBJECTIVE: To summarize the research progress and clinical application of nano-fat.METHODS: A computer-based online search of China Academic Journals Full-text Database, Wanfang database, VIP Chinese Technology Periodical Database, Pubmed database was performed to retrieve documents regarding nano-fat and adipose-derived stem cells with the search terms "nanofat, adipose-derived stem cells, fat grafting" in Chinese and English. Fifty-two publications were included in the final analysis.RESULTS AND CONCLUSION: The retrieved documents have demonstrated that nano-fat exhibits obvious effects in preventing against age and scar and on would repair and filling. However, sample size is small. A larger number of studies are required to support this conclusion.The currently prepared nano-fat contains multiple components. In-depth studies are required to investigate the precise mechanisms of action.There are no unified criteria to prepare nano-fat. Many links such as selection of fat source, method of sucking fat, mechanical emulsification and filtration of fat, and nursing after nano-fat transplantation should be further improved.