软聚硅酮泡沫敷料治疗放射性皮炎的Meta分析

Soft silicone foam dressing for the treatment of radiation dermatitis: a meta-analysis

背景:软聚硅酮泡沫敷料由软聚硅酮伤口接触层、聚氨酯泡沫吸收层和透气并防水的外覆薄膜3层组成,不仅有利于快速的肉芽组织生长,而且为伤口愈合提供了良好的湿性环境。目的:评价软聚硅酮泡沫敷料治疗放射性皮炎的效果。方法:应用计算机检索PubMed、Embase、Cochrane、中国学术期刊全文数据库、中国生物医学文献光盘数据库、万方数据平台和中文科技期刊数据库中关于软聚硅酮泡沫敷料应用于放射性皮炎的随机对照试验,检索时间均为建库至2018年10月。由2名研究生独立进行文献筛选、质量评价和资料提取。采用Revman5.3软件进行数据分析。结果与结论:共纳入6篇中文文献,包括416例放射性皮炎患者,其中观察组采用软聚硅酮泡沫敷料干预,对照组采用传统敷料、湿润烧伤膏和羊毛脂软膏中的一种进行干预。Meta分析结果显示:观察组放射性皮炎愈合时间短于对照组[MD=-6.36,95%CI(-8.72,-4.00),Z=5.28,P <0.000 01],放射性皮炎愈合率高于对照组[OR=5.67,95%CI(1.74,18.41),Z=2.89,P=0.004]。结果表明,软聚硅酮泡沫敷料应用于放射性皮炎的治疗效果优于其他敷料。

BACKGROUND: Soft silicone foam dressing is made up of 3 layers: soft silicone wound contact layer,polyurethane foam absorbing layer and breathable and waterproof outer covering film. It not only facilitates granulation tissue growth, but also provides a good wet environment for wound healing.OBJECTIVE: To evaluate the efficacy of soft silicone foam dressing in the treatment of radiation dermatitis.METHODS: Randomized controlled trials regarding soft silicone foam dressing applied to radiation dermatitis were searched by computer in PubMed, EMBASE, Cochrane, China Academic Journals Full-text Database,Chinese Biomedical Literature Database, Wanfang database and Chinese Science and Technology Periodicals Database.The retrieval time was limited to the period from database foundation to October 2018. Literature screening, quality evaluation and data extraction were conducted independently by two postgraduates. Revman 5.3 software was used for data analysis.RESULTS AND CONCLUSION: Six Chinese literatures were included, including 416 patients with radiation dermatitis. The experimental group was treated with soft silicone foam dressing, while the control group was treated with traditional dressing, moist exposed burn ointment or lanolin ointment. Meta-analysis results showed that the healing time of radiation dermatitis in the experimental group was shorter than that in the control group [MD=-6.36, 95%CI(-8.72,-4.00), Z=5.28, P < 0.000 01]. The healing rate of radiation dermatitis in the experimental group was significantly higher than that in the control group [OR=5.67, 95%CI(1.74, 18.41), Z=2.89, P=0.004]. The results suggest that soft silicone foam dressing exhibits better therapeutic effects on radiation dermatitis than other dressings.