原发性肺癌患者血清ADH、TNF-α水平与其预后关系研究

Relationship between Serum Levels of ADH and TNF-α and Prognosis in Patients With Primary Lung Cancer

目的探究原发性肺癌患者血清抗利尿激素(ADH)、肿瘤坏死因子α(TNF-α)水平与其预后之间的关系。方法选取2017年12月-2018年12月期间收治的40例原发性肺癌患者,全部给予手术切除治疗,设其为研究组;选取同期采取生化检验的40例健康体检者,设其为对照组。对比两组术前ADH与TNF-α水平,并观察术前、术后1~14 d研究组患者的血清ADH与TNF-α水平变化。结果研究组术前血清ADH与TNF-α水平均高于对照组,差异有统计学意义(P <0.05)。研究组术后5~14 d的血清ADH与TNF-α水平低于术前,差异有统计学意义(P <0.05)。结论临床可以通过血清ADH和TNF-α水平的测定来评估原发性肺癌患者的预后。

Objective To investigate the relationship between serum levels of antidiuretic hormone(ADH) and tumor necrosis factor alpha(TNF-α)and prognosis in patients with primary lung cancer. Methods Forty patients with primary lung cancer who were admitted between December 2017 and December 2018 were enrolled in the study group. They were selected as the study group. 40 healthy subjects who took biochemical tests at the same time were selected as control group. The levels of ADH and TNF-α were compared between the two groups. The changes of ADH and TNF-α levels in the study group were observed before operation and 1 to 14 days after operation. Results The levels of ADH and TNF-α in the study group were higher than those in the control group(P < 0.05). The levels of ADH and TNF-α in the study group 5 to 14 days after operation were lower than those before surgery(P < 0.05). Conclusion Clinically, the prognosis of patients with primary lung cancer can be assessed by measuring serum levels of ADH and TNF-α.