摘要
前列腺素E2(prostaglandin E2,PGE2)作为体内极为重要的一种脂代谢产物,在受到各种生理或病理刺激时被释放,并通过特异性的受体发挥其在炎症反应、血压调节中的生物学作用。PGE2作用的受体主要有4种亚型(Eprostanoidreceptors,EP1、EP2、EP3和EP4),因其所介导的作用之间存在相互拮抗的关系,PGE2对心血管系统的作用非常复杂,通常由在特定器官或组织中的优势受体所决定。本文主要从受体作用特点的角度对PGE2在动脉粥样硬化、血栓形成、高血压、脑卒中等心血管疾病中的作用研究进行分析和总结,为阐明其可能的发病机制提供新的思路。
Prostaglandin E2(PGE2), an extremely important arachidonic acid metabolite in the body, is released when stimulated by various physiological or pathological stimuli and mediates inflammatory response, regulates blood pressure, and is involved with other biological effects through specific receptors. There are four kinds of specific receptor subtypes(E-prostanoidreceptors, EP1, EP2, EP3 and EP4) in the body which mediate the effects of PGE2. However, given the antagonistic effects mediated by these four subtypes, PGE2 has a complex effect on the cardiovascular system, which is usually determined by receptor subtype in specific organs or tissues. This review summarizes the latest research related to PGE2 in cardiovascular diseases, includiong atherosclerosis, thrombosis, hypertension, and stroke from the perspective of receptor action characteristics, aiming to provide new ideas in PGE2 role in cardiovascular pathogenesis.
作者
石特
谭兴
王伟忠
王杨凯
SHI Te;TAN Xing;WANG Wei-zhong;WANG Yang-kai(Fifth Cadet Team,Navy Military Medical University,Shanghai 200433,China;Department of Physiology,School of Basic Medical Sciences,Navy Military Medical University,Shanghai 200433,China)
出处
《心脏杂志》
CAS
2019年第3期339-342,共4页
Chinese Heart Journal
基金
国家自然科学基金项目资助(81770419)
