4039例孕前优生检查待孕夫妇的乙肝两对半检测结果

Detection results of hepatitis B two half-and-half among 4 039 cases of pre-pregnancy eugenics examination couples

目的分析天津市滨海新区大港地区待孕夫妇在孕前优生检查中的乙型病毒肝炎(乙肝)两对半的结果,为控制乙肝病毒的母婴传播提供参考依据。方法选取2016年3月—2018年11月在天津市滨海新区妇女儿童保健和计划生育服务中心大港分中心接受孕前优生检查的待孕夫妇,采用酶联免疫法(ELLSA法)进行乙肝两对半检测,结果按照乙肝表面抗原(HBsAg)、乙肝表面抗体(HBsAb)、e抗原(HBeAg)、e抗体(HBeAb)和核心抗体(HBcAb)的阳性结果进行分析。结果 4 039例受检夫妇中HBsAb阳性者2 137例,占52.91%。五项全阴者1 539例,占38.10%。乙肝感染者110例,占2.72%。其中乙肝感染率男性(3.38%,64例)高于女性(2.15%,46人)。按照年龄组分别统计,≤29岁年龄组乙肝感染者占本年龄组人数的1.60%,30～39岁年龄组感染率占3.86%,≥40岁年龄组感染率占5.28%。结论男性感染乙肝的比例大于女性,乙肝患病率随着年龄的增长逐渐增高,应对这部分人群进行重点干预,促进优生优育。

[Objective]To analyze the detection results of hepatitis B two half-and-half in pre-pregnancy eugenics examination among preparing pregnant couples in Dagang District of Binhai New Area in Tianjin,and provide reference basis for controlling the mother-to-child transmission of hepatitis B virus.[Methods]The preparing pregnant couples received pre-pregnancy eugenics examination in Dagang sub-center of Tianjin Binhai New Area Women and Children’s Health and Family Planning Service Center from March 2016 to November 2018 were selected,the hepatitis B two half-and-half was detected by enzyme-linked immunosorbent assay(ELLSA). The results were analyzed according to the positive results of hepatitis B surface antigen(HBsAg),hepatitis B surface antibody(HBsAb),e antigen(HBeAg),e antibody(HBeAb),and core antibody(HBcAb).[Results]Among 4 039 couples,2137 were positive for HBsAb,accounting for 52.91%. There were 1 539 cases with five indicators all negative,accounting for 38.10%. There were 110 cases of hepatitis B infection,accounting for 2.72%. The infection rate of hepatitis B among males(3.38%,64 cases) were higher than that among females(2.15%,46 cases). According to the age group,the hepatitis B infected cases aged ≤29 years old accounted for 1.60% of this age group,the infection rate of the age group of 30-39 years old was 3.86%,and over 40 years old was 5.28%.[Conclusion]The proportion of men infected with hepatitis B is greater than that of women,and the prevalence rate of hepatitis B increases with age. Therefore,we should focus on the intervention on this group to promote prenatal and postnatal care.