疏肝健脾法治疗活动期甲状腺相关眼病的临床观察

Clinical observation on treatment of active thyroid-associated ophthalmopathy with soothing liver and invigorating spleen method

目的探讨疏肝健脾法治疗活动期甲状腺相关眼病(TAO)的疗效。方法选择符合条件的60例甲状腺相关眼病患者随机分为两组,其中治疗组30例(60只眼)给予口服中药“疏肝健脾方”联合甲强龙冲击治疗,对照组30例(60只眼)给予注射用甲基强的松龙冲击治疗,两组疗程均为12周。观察两组治疗前后CAS评分、眼球突出度变化情况。结果两组临床疗效比较差异无统计学意义(P>0.05),但治疗后两组CAS评分、突眼度均明显降低(P均<0.05),且治疗组各指标改善程度均明显优于对照组(P均<0.05)。结论疏肝健脾法能有效改善TAO患者CAS评分、眼球突出度症状。

OBJECTIVE To investigate the therapeutic effect of soothing liver and invigorating spleen on active thyroid-associated ophthalmopathy(TAO).METHODS Sixty patients with TAO were randomly divided into two groups,the 30 cases(60 eyes)of treatment group were given Chinese Shugan Jianpi formula by combination with pulse methylprednisolone therapy,while the 30 cases(60 eyes)of the control group were treated with pulse methylprednisolone therapy,and the treatment courses of two groups were both 12 weeks.The CAS scores and exophthalmos of the two groups before and after treatment were observed.RESULTS There was no significant difference in clinical efficacy between the two groups(P>0.05),but the scores of CAS and exophthalmos decreased significantly in the two groups after treatment(P<0.05),and the improvement of each index in the treatment group was significantly better than that of the control group(P<0.05).CONCLUSIONS The method of soothing liver and invigorating spleen effectively improved the CAS scores and exophthalmos symptoms in TAO patients.