三阴性男性乳腺癌1例

Triple-negative male breast cancer:a case report

报告1例三阴性男性乳腺癌。患者男,65岁。右侧乳晕结节2个月。皮肤科检查:右侧乳晕旁一3.0cm×3.0cm红色结节,质韧,表面可见糜烂及痂皮,边界清,活动度差。皮损组织病理检查:真皮及皮下组织内可见浸润性腺癌,肿瘤细胞胞质嗜酸,间质可见淋巴细胞等炎性细胞浸润。免疫组化示CK7(+)、GATA-3(+)、雄激素受体(AR)(++)、人表皮生长因子受体(HER)-2(++)、巨大囊肿病液体蛋白(GCDFP)-15(+++)及增殖核抗原(Ki)-67(约10%+),雌激素受体(ER)及孕激素受体(PR)均0分,符合乳腺或大汗腺来源。双色银染原位杂交(DISH)检测示HER-2基因无扩增。诊断:三阴性男性乳腺癌。

A case of triple-negative male breast cancer is reported. A 65-year-old male presented with a 2-month history of red nodule on the right areola. Dermatological examination revealed a well-demarcated firm red nodule with poor mobility,sized 3.0 cm ×3.0 cm, on the right areola, topped with erosive and exudative crusts. Histopathological examination showed invasive adenocarcinoma in the dermis and subcutaneous tissue, originating from mammary or apocrine glands. The cytoplasm was eosinophilic, interstitial infiltration of inflammatory cells such as lymphocytes were observed. Immunohistochemical staining showed that tumor cells were positive for CK7, GCDFP-15, GATA-3, AR, Ki-67, HER-2, and negative for ER and PR. DISH analysis showed no amplification of HER-2 gene. Diagnosis of triple-negative male breast cancer was made.