磁共振T_1、T_2-Mapping技术评价2型糖尿病患者早期晶状体改变的可行性研究

Quantitative Assessment of Early Lens Disease in Type 2 Diabetic Patient using T_1、T_2-Mapping Techniques

目的探讨T_1、T_2-Mapping技术在评价2型糖尿病早期晶状体并发症的可行性。方法前瞻性搜集28例裂隙灯检查晶状体正常的2型糖尿病患者,并搜集同期来医院就诊的非糖尿病患者28例为对照组。糖尿病组及对照组均接受眼部MRI扫描,采集T_1、T_2-Mapping图像。晶状体T_1、T_2值测量采用感兴趣区(ROI)方法(ROI面积0.04 cm^2,ROI置于晶状体核中心位置)。采用两样本t检验评价糖尿病组与对照组晶状体核弛豫时间的差异。结果糖尿病患者晶状体核T_1值为626.7±56.8,T_2值为29.4±5.6;对照组T_1值为581.6±64.7,T_2值为24.8±8.6;糖尿病组T_1值(t=3.91,P<0.05)及T_2值(t=3.34,P<0.01)较对照组均显著增加。结论 2型糖尿病患者病程中晶状体T_1、T_2值显著增高,T_1、T_2-mapping技术能够敏感检测2型糖尿病患者裂隙灯检查阴性的早期晶状体核弛豫时间变化。

Objective To explore the feasibility of T1 and T2-Mapping in evaluating the relaxation time of the nuclear lens in Type 2 diabetic patient. Methods 28 patients with type 2 diabetes in both eyes were compared with 28 healthy control patients. All patients underwent orbital MRI examination with T1 and T2-Mapping on a Siemens-SKY. 3.0 T scanner. T1 and T2 values of the lens nucleus were measured by ROI method based on Siemens-Syngo workstation. Two samplet test were used to analyze the differences between groups. Results In type 2 diabetes group,the T1 value was( 626. 7 ±56. 8),T2 value was( 29. 4 ± 5. 6). In healthy control group,the T1 value was( 581. 6 ± 64. 7),T2 value was( 24. 8 ±8. 6). The T1 values( t = 3. 91,P < 0. 05) and T2 values( t = 3. 34,P < 0. 01) of the lens nucleus in the diabetic group were significantly higher than those in control group. Conclusion The relaxation time of lens nucleus was significantly higher in patients with diabetes. T1 and T2-mapping technique can sensitively detect the changes of the relaxation time of the lens nucleus in diabetic patients.