细胞焦亡与动脉粥样硬化

Pyroptosis and atherosclerosis

动脉粥样硬化是缺血性血管疾病的重要病因之一,炎症和细胞死亡在其发生发展过程中发挥重要作用。而细胞焦亡是一种促炎性细胞程序性死亡。最近的研究表明,内皮细胞、巨噬细胞及平滑肌细胞的焦亡加速了动脉粥样硬化进程。因此更好地了解细胞焦亡可能为预防和治疗动脉粥样硬化相关疾病提供新方法。现就细胞焦亡与动脉粥样硬化的关系作一综述。

Atherosclerosis is one of the most essential causes of ischemic vascular disease,while inflammation and cell death play an important role during its development. Pyroptosis is a programmed pro- inflammatory ceil death proess. Recent studies have shown that the pyroptosis of endothelial cells, macrophages and smooth muscle cells accelerates the progress of atherosclerosis. Therefore, It may provide us a new method for the prevention and treatment of atherosclerosis-related diseasesa to have a better understanding of pyroptosis. This article aims at reviewing the relationship between pyroptosis and atherosclerosis.